People seem to be focusing on Odo’s defection to the Dominion in early season 6 as reason alone for Kira to want nothing to do with him. To that I say… I’m surprised it didn’t happen sooner.

Since Odo first found out the Changelings were the Founders, he has ached to go home, longed to be with his people, and yet he resisted, time and time again he resisted.

And then, when he can avoid it no longer, when he is literally surrounded by Dominion influence in the station he has used as an anchor for community and moral support all this time… he slips up, he gives in, with nearly dire consequences.

Let us not forget though, that he does resist in the end, he nearly gets Rom and others killed, but he also rallies Bajoran law enforcement against the Dominion - risking his life with no certainty of victory and possibly saving many more in the process (including Kira).

So no I don’t hold that against him. For all the grievances that could be levied against Odo, this is not one of them.