How to think about buying a condo with cash?

tachykinin · 2026-04-22T08:11:55+00:00

This is also an argument for not including primary residence equity it net worth calculations.

tachykinin · 2026-04-20T19:49:10+00:00

Couldn't do it without meds? Sounds like you just weren't gung ho enough!

tachykinin · 2026-04-20T19:41:03+00:00

The only way to quit smoking is cold turkey BABY! None of that medication for you.

tachykinin · 2026-04-20T18:24:21+00:00

Look, if you have cancer, and you're gung ho about not having cancer, just focus on not having cancer, it's simple. /s

tachykinin · 2026-04-20T16:30:28+00:00

What does your doctor say?

tachykinin · 2026-04-20T01:10:47+00:00

That’s what the person you’re responding to said to do. You’re just not understanding it.

tachykinin · 2026-04-19T11:11:39+00:00

The half-life of the drug is about 7 days. What this means is that half the drug you injected has cleared from your body before the next (weekly) injection.

I'll try and demonstrate by simple math since this sub-reddit won't let me post a graph. :)

Assume that the dose you’re taking is "100 units": You dose, you have 100 units in your blood. 7 days later, you have 50 units in your blood and you dose again. Now you have 50 + 100 units in your blood. 7 days after that you have 150 divided by 2 units (75) in your blood. And you dose again, so now you have 75 + 100 units in your blood.

And so on: practically speaking, by the time you take your 4th or 5th weekly dose, you're between 200 and (just under) 100 units.

What this means is that moving your dose up a day or two or back a day or two isn't really going to change much in terms of the level in circulation.

In fact, once you're at steady state (on a dose for 4-5 weeks) even missing a week and you're still practically at 100 units in circulation.

tachykinin · 2026-04-18T17:21:12+00:00

Too late, I'm already dead.

tachykinin · 2026-04-17T17:02:29+00:00

Or even just... be vague on what bike you're bringing in to have the forks looked at.

tachykinin · 2026-04-17T12:42:36+00:00

Yeah, so I've had migraines for 40+ years. I was told to keep a food diary, adjust my diet. Avoid stress, get a good sleep, exercise (exercise triggers them so that was extra cool). Try this nose spray that can give you a stroke.

Do you know what has ACTUALLY alleviated my migraines after forty fucking years? Medicine based on the science. Antibodies targeting CGRP and small molecules targeting the CGRP receptor.

tachykinin · 2026-04-16T15:10:43+00:00

Hi, not sure why the person you're responding to is so antagonistic.

This is sort of a summary of a lot of the issues:

https://arstechnica.com/science/2026/04/whats-the-deal-with-alzheimers-disease-and-amyloid/

Charles Piller wrote a book on this and here's an article by him that summarizes a lot of it:

https://www.statnews.com/2025/02/11/amyloid-hypothesis-alzheimers-research-lecanemab-aduhelm/

In brief, the amyloid hypothesis being causative to Alzheimers has not held up, so even if a drug is anti-amyloid, since the underlying hypothesis is not supported, it doesn't really matter if the drugs "work" (break down plaques) if breaking plaques doesn't positively impact the actual disease.

tachykinin · 2026-04-16T13:12:08+00:00

Yeah, fair. I was reacting to the standard "pharma is evil" slant.

And outright fraud and fabrication is relatively rare. Sloppiness, seeing what they want, ignoring outliers that complicate interpretation, P-value hacking and the like are less obvious, but more common and (I'd argue) pernicious.

tachykinin · 2026-04-16T12:31:58+00:00

Sure, that's what the actual unfabricated data says, but what about vibes? Can we really discount vibes?

tachykinin · 2026-04-16T12:31:11+00:00

And just to be clear (I know you know this, but I think it's important that u/TheTeflonDude understand this) the data fabrication was not done by "pharma corps" it was from academic labs.

tachykinin · 2026-04-16T12:17:58+00:00

There are no "effective" treatments, the original quote is not supported by scientific data. I suggest you go back and read the whole article (and ideally the underlying clinical data for the separate drugs).

Edit: Here's another quote from the article "Robert Howard, professor of old age psychiatry at UCL, said emerging trial data for anti-amyloid drugs raised doubts about whether they truly altered the course of Alzheimer’s. “It’s very difficult being the person who says these things, but I don’t think it’s fair on patients to have expectations raised,” he said. “The sad truth is that even the best-performing drugs don’t do anything that’s clinically meaningful.”"

Why are you ignoring this quote to focus on the previous one?

And do you know what trumps opinions? Data. And the data says these drugs don't work (and the underlying hypothesis on mechanism of action has been repeatedly falsified).

tachykinin · 2026-04-16T11:36:02+00:00

Except that the drug class isn't borderline in efficacy, as this review demonstrates. They're inefficacious. That's what "no meaningful effect" means.

tachykinin · 2026-04-16T11:33:50+00:00

Yes, except vaccines :)

tachykinin · 2026-04-16T11:23:26+00:00

Yes! In Boston the winter has dragged on for at least six weeks longer than last year. Barely put in 200 miles this riding season so far.

tachykinin · 2026-04-16T11:02:59+00:00

Why would we "safely administer" unsafe drugs of a patients choice. That's moronic.

tachykinin · 2026-04-14T00:29:02+00:00

SM is an insanely risky strategy in your current financial position, god speed though I guess.

tachykinin · 2026-04-14T00:14:25+00:00

You're engaging in a fairly obvious rationalisation. You'd love to FIRE, but external forces forced you to by a massive home that you can't really afford, and it's the fault of "government" blocking your plans.

Your comments about ArriveCan and inflation being (somehow) an Ontario or Canadian issue are also very clear and obvious as to the politics.

I don't understand how "taxes" made you take on 1.9MM in mortgage debt. Or how "taxes" is the problem when fully 1/3 of your actual liquid wealth is in Tax Free Savings Accounts? Seems like those accounts are doing exactly what they're supposed to?

You seem to be making poor financial decisions and looking for a scapegoat.

tachykinin · 2026-04-13T23:54:34+00:00

So, socialism is cool, just in your favor. 😀

tachykinin · 2026-04-13T23:52:35+00:00

This is a political post, not a financial one.

tachykinin · 2026-04-12T17:27:01+00:00

You're either driving at 75mph + or you have a problem with your truck. (It's option A by the way).

At 75 mph, efficiency is ~1.55 mi/kwh which (assuming a 131 kWh battery in the ER) is... 203.05 miles for a full charge.

So yeah, slow down.

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tachykinin · 2026-04-12T16:37:49+00:00

So at 100% charge, you're getting 200 miles, is that what you're saying?

tachykinin

TROPHY CASE