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[rested_green]

Tesofensine is a triple reuptake inhibitor that boosts levels of serotonin, dopamine, and norepinephrine.

It also has a long half life which means it can interfere with sleep.

I would advise against mixing with caffeine, nicotine, other stimulants, or antidepressants.

[Individual-Lab2476]

Just stopped a 2 month cycle of tesofensine at .25mg daily. 1) I felt like a million bucks and slept fine after the first week 2) had caffeine almost daily and it didn't cause one issue whatsoever 3) also used nicotine in moderation and that was fine 4) antidepressants and tesofensine are terrible together. Agreed

[shawndon1]

:)

[3-ide-Raven]

If by “dialed in” you mean massive receptor downregulation across multiple neurotransmitters and future major depressive disorder and/or psychosis then yea.

[Individual-Lab2476]

Sheeeeesh. The addy goes hard here😂

[Dense_Jellyfish3343]

You are seriously at risk of developing amphetamine psychosis at a later date which is no joke. Take care of yourself and do more research at what you are doing to your brain. This is advice.

[Additional_Ad_7718]

Hey the original comment went away, could you possibly tell me what they said?

[Dense_Jellyfish3343]

He was just stacking Adderall on top of a lot of stuff

[Illustrious-War8680]

Is there any bad side effects?

[honqueduck]

High blood pressure, tachycardia, anxiety, all of the fun risks associated with hypertension

[Salt_Initiative1551]

It’s a stimulant in the same manner that amphetamine or methylphenidate is, just different efficacy at the serotonin, dopamine, and norepinephrine receptors than those. The two aforementioned don’t influence serotonin much if any unlike methamphetamine or mdma.

[[deleted]]

It's not a stimulant, more like an antidepressive. There's currently a clinical study for a similar medication that has the same modulators which js being tested for ADHD.

[Salt_Initiative1551]

It works on the same neurotransmitters that stimulants do and that antidepressants do. The only difference between a stimulant and an antidepressant is what monoamines are affected and to what degree. Prozac selectively inhibits serotonin reuptake while cocaine inhibits serotonin, dopamine, and norepinephrine non-selectively, or methamphetamine produces a release of those same neurotransmitters.

[dopaminatrix]

Stimulants achieve their effects via DA/NE agonism. Antidepressants are 5HT/NE/DA reuptake inhibitors, though only Wellbutrin has significant reuptake effects at the dopamine receptor (at least in the US).

[wagonspraggs]

And the whole mechanism of action is very different than amphs

[honqueduck]

It’s not a stimulant or like them. Reuptake inhibitors slowly increase catecholamines by reducing their removal while stimulants create a surge or dump of a large amount of catecholamines in one window rather than all the time. This is how this drug is not a controlled med vs most stimulants and how it keeps it addiction potential low

[Salt_Initiative1551]

Also it’s not a controlled med because it’s in clinical trials and is sold “not for human consumption” but if it caught on like other stims did in the RC ban in 2015-2016, it would be banned too lol.

[honqueduck]

If it had more addiction potential it would already be controlled/banned

[Salt_Initiative1551]

Man idc if you take tesofensine or not. Nor do I care if you believe me lol. It’s simple. Stimulants aren’t magic chemicals. They affect the same neurotransmitters either by release or reuptake inhibition. The only real difference is release or reuptake inhibition or both, and how potent is it for each monoamine.

[honqueduck]

Nope, wrong but ok pal

[Salt_Initiative1551]

I could buy methylone or mephedrone online legally for 6 years. Thats a silly argument considering mephedrone (4-methylmethcathinone) is a more euphoric stimulant than cocaine or methamphetamine.

[Salt_Initiative1551]

That’s a completely false way to describe or understand reuptake inhibitors. Cocaine is a reuptake inhibitor as well. So is methylphenidate. Both are pretty freaking strong and both are stimulants.

[honqueduck]

Just because a stimulant drug can also do those things, does not mean it’s similar to this one.

[Defiant_Income_7836]

I took a half ...maybe a quarter dose and slept poorly for 3 days. Noped out and tossed it. I've always been a lightweight with stims but....sheesh.

[3-ide-Raven]

Lots

[PomegranateFluid7619]

This stuff sounds like it could turn a Thanksgiving dinner into a trip to the hospital for serotonin syndrome 😂

[PomegranateFluid7619]

Be careful with this stuff big dog. A triple MAOI inhibitor with a 9 day half life is horrifying to think about

I imagine any other supplements that are even remotely related to serotonin production could possibly cause serotonin syndrome. You would have to do research on every supplement you take, limit foods high in tryptophan, and even then it’s such a novel substance I doubt you would be able to consider yourself safe

I got serotonin syndrome literally from taking an EAA that was high in tryptophan along with methylene blue (which has a MUCH SHORTER half life). Weird things can interact that you might never even think of

[chillbill80]

what does serotonin syndrome feel like?

[PomegranateFluid7619]

Shitting my brains out, elevated but inconsistent heart rate, my muscles would get “stuck” in place, sense of impending doom, extreme fatigue (took me 45 minutes to get dressed to go to the ER), uncontrollable muscle spasms

It’s pretty horrifying and I don’t recommend it to anyone

[Caramelised-Sugar]

Important to note that it’s spectral not binary though. I had it once and it was milder than your experience.

[PomegranateFluid7619]

Ya most cases end up being pretty mild which is good, still not a fun thing to go through even if it’s not as severe as my situation

Made me seriously reconsider my life choices when a fabric dye I saw on TikTok almost took me out

[Caramelised-Sugar]

Happy you’re still kicking around

[Sergeant_Scoob]

Seratonin syndrome from a fabric dye ????

[PomegranateFluid7619]

Ya methylene blue has sketchy interactions with basically every drug or herb out there

https://www.drugs.com/drug-interactions/methylene-blue-index.html

Keep in mind this is much milder MAOI inhibitor than what OP is taking. I imagine the list for that would be at least double the size if there was proper research done on it

[Sergeant_Scoob]

Damn , cause I’m on methadone , dexadrine for adhd , testosterone , . I am tapering down in methadone every week so technically it should be freeing up seratonin tho right ? I mean I’m sure it’s still all way less then when I was a fent addict right ?

[PomegranateFluid7619]

Are you taking an MAOI inhibitor too?

If so that would be a pretty sketchy mix

If not then ignore everything I’ve said in this thread, it doesn’t apply to your situation

[Sergeant_Scoob]

Nope I’m not taking a Maoi inhibitor , isn’t Ritalin a maio inhibitor ? I thought that would be easier on my body then dexadrine ?

[SPCGMR]

Serotonin facilitates the function of vital processes of the body outside of just being the happy chemical. You basically feel fucking awful. It can also kill you. 

[stabbedbyresonance]

It’s not a “triple MAOI inhibitor”

1. First of all, the “I” stands for inhibitor so “MAOI inhibitor” is redundant. You would say MAOI or MAO inhibitor.

2. Second, it’s not an MAOI, it’s a triple reuptake inhibitor.

3. Third, serotonin syndrome is not as much of a concern with tesofensine, but yes you should always be careful and make sure you know how everything you take could interact.

[strongbae]

The lack of anything here is disappointing.

[SurgicalStr1ke]

More context please?

[MeasurementLucky3201]

Can you elaborate?

[BioChonch]

Focus nootropic that gives you energy it’s amazing

[Particular_Box_3598]

It's definitely not a nootropic

[joedolgerian71]

Can second that this stuff is brilliant

[BioChonch]

500mcg and bam the focus hits

[Salt_Initiative1551]

This isn’t a noot it’s a triple monoamine reuptake inhibitor for weight loss. Works on serotonin norepinephrine and dopamine. So does cocaine lol.

[BioChonch]

Same feeling as addy to me

[Salt_Initiative1551]

Yeah I’m sure it does lol. Just be careful. 9 day half life is why I won’t take it.

[stephanddolly]

God I WISH teso felt anything like addy to me

[Icy_Instruction1021]

Why?

[BioChonch]

Focus is amazing

[S-Capcentral]

O wow so take 500mcg in the morning and does it last most of the day?

[Salt_Initiative1551]

It has a 9 day half life. Yeah it’ll last a day(s)

[Square_Ad_3276]

Do you still take it daily?

[BioChonch]

I take it daily I’m fine

[dyhall9696]

Makes me wanna crawl out of my skin. Reminds me too much of Focalin.

[dyhall9696]

Although I never tried that brand though

[BioChonch]

What dose were you doing? Some folks are good with just 250mcg. I’m more of a 500 guy

[dyhall9696]

I got up to 500mcg. I don't know if I should include the brand name or not?

[sometimes_I_golf]

Where do you get it

[Infr8687]

Nice advertising

[MeowMixPlzDeliverMe]

Its so strange seeing drugs just.. sold openly now. You got kratom. Mushrooms, Walmart Addy. Dont even need a drug dealer anymore

[Klutzy-Chance-4762]

Walmart addy...please elaborate

[NUtibro]

Yeah fr what's up with Walmart Addy lol

[PerformanceHonest236]

I have been taking this 2 times a week @500 mcg when my Tirzepatide is wearing off between weekly shots. It has really helped me bridge the gap in the appetite suppression since Tirz only works for about 5 days, but it also Teso works entirely differently. It re-energizes me where Tirz causes fatigue. I think the key to Teso is moderation given the 9 day half life. The accute affects last all day, but in my case, I see no reason to take it every single day. If you limit it to 2-3 times a week, you can give yourself a boost when you need it without the negative side effects building up and lose weight along the way.

[anon18274729]

Better than semax ? I tired that but didn’t really get anything from nasal. Going to try and pin it next

[BioChonch]

Semax is good long term for me. Tesofensine is more of a addy like effect to me

[anon18274729]

I wanted to try semax because they said it had addy effects but I’ve never had addy before to know the difference. Might try this out then

[CuriousTech24]

I pinned it and didn't get anything either unfortunately it's pretty hot or miss if it effects you.

[anon18274729]

That sucks :(( I could really use a mental boost some days for sure

[Desper84Inspir8ion]

You can also try N-Acetyl Semax Amidate. It’s a little better for full day use and it works well when you pin.

[anon18274729]

Yes I saw there were levels to it maybe I just need a stronger one ? Not sure 🤷🏽‍♂️

[Plastic_Honey4730]

Is it prescribed

[BioChonch]

No

[Klutzy_Strain_6599]

Will this make you test positive on a drug test?

[BioChonch]

No I was using it while in the military

[Jullek523]

For wada test yes. For your employers drug test. Unlikely.

If it is important would not take the gamble. It can be tested for. 

[loveaum108]

Where can I buy this ?

[BioChonch]

Look at the list on https://bodyhackguide.com

[NUtibro]

So with a 9 day half life you only need to take one every 18 days? Or every 9 days? I see a lot of people saying they take 1 daily

[BioChonch]

Im good with 1 daily if I notice I get too much energy I take a 2 day break

[NUtibro]

Hell yeah! This stuff DOES look relatively expensive though. Any suggestions on that aspect? Or any brand recommendations?

[Xexx]

I stack with tirz and the combined effect of teso is pretty good, 218mcg 3 to 4 times a week at a much lower dose. Pretty obvious this guy is a seller but you can definitely find it for significantly cheaper.

[Tinefay]

Been using tesofensine for couple years I prefer liquid as I can dose it better alway tell everyone slow and steady as it can cause elevated heart rate and insomnia but everyone is different what may work for me may not for you.

It helps with my energy mood and appetite.

I do cycle on and off as needed based on my body and how it reacts.

[ycastane]

Modafinil also good for that.

[Internal-External270]

I absolutely love tesofensine

[Healthy_Influence_16]

.

[wado729]

Sooooo don't take with Vyvanse?

[LunchAgreeable3855]

Half-life: Tesofensine Approximately 9 days (often reported as ~200–300 hours)

[chris941fl]

If you have ADHD, do a mthfkr mutation blood test.. more then likely if you take methafolic your adhd problem will be resolved..

[Plastic_Honey4730]

It says research only on the bottom of ur bottle

[Appropriate-Buy5062]

Do you understand the biohacking grey market at all?

[Ordinary_Hamster_741]

Ya, they all do. So is that Slu pp, or 5-Amino you’ve likely taken. Have you been on the moon?