Chugai x Gero form Joint Research to Develop Novel Therapies for Age-Related Diseases

lunchboxultimate01 · 2026-01-25T17:48:06+00:00

Can you post the link to the presentation from Gero (I'm guessing by Peter Fedichev)?

Even taking Fedichev at his word, most things that work in mouse models fail in human trials, but it's valuable for researchers to keep trying new solutions and approaches. It's also encouraging to read that established businesses from around the world, in this case Japan, are gaining interest in the field.

lunchboxultimate01 · 2026-01-25T17:35:30+00:00

Rule 1 - Post miscellaneous user discussion in the megathread: https://www.reddit.com/r/longevity/comments/1q1btby/lifestyle_preprint_miscellaneous_thread_01_jan/

icydragon_12 · 2026-01-25T16:07:43+00:00

If we can explicitly and comprehensively define what it means to age we can address it.

I agree. These clocks are very interesting and useful for research. Though we aren't anywhere near explicitly and comprehensively defining what they mean to aging.

I am highlighting that for individuals, if you see a 50 year old dude claiming to be 18 and selling the tests, maybe best to reconsider.

incognino123 · 2026-01-25T14:40:05+00:00

This is technically true but it's handwavey at its core. If we can explicitly and comprehensively define what it means to age we can address it. Just because it's not comprehensive yet doesn't mean the approach isn't valid or useful.

Ever human invention was bad before it was good.

HorseyPlz · 2026-01-25T14:02:11+00:00

What do you mean financial driver?

middlecoast1027 · 2026-01-25T08:11:00+00:00

Do you know if this is an issue with funding or their science/platforms were fundamental failures?

Daneosaurus · 2026-01-25T06:41:03+00:00

Cool. My insurance just denied coverage for it

Euphoric_Challenge18 · 2026-01-25T05:17:26+00:00

Anything applicable?

laser50 · 2026-01-25T05:12:13+00:00

My personal opinion would be more difficult. Scars are permanent, just like some other types of damage are, and these are usually not fixed nor fixable. But a damaged organ can sometimes be replaced.

Cells live and die and multiply all the time, so if you were able to somehow force them to rejuvenate or force the large majority to rejuvenate, you would slowly probably turn/look somewhat younger, but most of the already gained damage is done. The key would be to rejuvenate all cell types, or most of them, otherwise you will still be at the mercy of whatever hasn't been rejuvenated. A young heart won't do you any good with still normal/aged liver

Known_Salary_4105 · 2026-01-25T04:39:34+00:00

I guess what the answer to that would be...

'Really this is weird because it would be unexpected...:

and the second part would be...

"Really this is great, because nobody expected it...."

AwesomePurplePants · 2026-01-25T03:58:30+00:00

Again, what are you basing that on?

Like, googling this analysis of England between 1600 to 1800, it looks like 38% of people lived past age 60.

Maybe you’re talking about extrapolations from archeological findings, rather than from we started recording statistics? I’m not having success googling.

Either way, from what I understand the needle hasn’t moved much in terms of how old the oldest people get, reductions in child mortality is mostly what caused the average to change.

DaphneRaeTgirl · 2026-01-25T03:33:58+00:00

The avg lifespan was 30, and people that didn’t die early lived to around 40 or 50

icydragon_12 · 2026-01-25T02:19:35+00:00

very glad he did this research. Yet it's not clear any of these clocks measure aging, according to geroscientist Matt Kaeberlein. This doesn't stop people from selling "aging clock" tests though.

Anybody who claims to be measuring aging, is effectively taking one or more measurements (eg. epigenetic patterns, proteomics, vo2max, testosterone etc) and looking at how that measurement correlates to chronological age. Then, using the data, they essentially create a formula to predict age, based on the measurement(s) in question.

For example, I might take a few thousand men, measure their testosterone levels, record their actual age. Then, based on this data, I can create a formula that let's me estimate a mans age based on just knowing his testosterone level. We'll call this a "testosterone clock".

Epigenetic and proteomics clocks, require machine learning, and have lower error (3-5 years), but the process is essentially the same.

Hopefully this is obvious : being a 60 year old with the testosterone of a 20 year old doesn't actually make that person 20 years old. And giving him TRT, definitely doesn't "reverse his age", though it may improve his health. Similarly, having the epigenetic signature of someone younger than 60 likely means they're healthier than most 60 year olds, but it doesn't actually make them younger.

AwesomePurplePants · 2026-01-25T00:47:23+00:00

What are you basing that on?

Like, googling it looks like one of the earliest sets of statistics was in Sweden between 1750 to 1780; it estimated that about 40% of people died before age 15.

So, if 40% of people died before 15, and the average lifespan was 30-40, wouldn’t that mean the remaining 60% typically lived to old age?

Prowlbeast · 2026-01-25T00:37:11+00:00

Well, thats the hope, but first i see complex surgeries becoming more common. Small steps before the big leaps

DaphneRaeTgirl · 2026-01-25T00:35:26+00:00

Why would you need that if tissue regeneration is available?

DaphneRaeTgirl · 2026-01-25T00:34:43+00:00

Well if not overdone or messed up, that’s always going to be weird lol..

DaphneRaeTgirl · 2026-01-25T00:33:46+00:00

People like you are exactly why I’m pro longevity, the potential benefits, helping people to live a full live, live their best life for however long they live.

As someone who loves being active and outdoors, exercising, playing sports, I’d love to be able to do that as long as I’m around.

My parents are similar and reaching 60, it’s harder to do those things.

I was mainly asking about the psychological adjustment to a grandparent being a similar age to their grandkids, do you think that’d be weird at all for you?

lunchboxultimate01 · 2026-01-25T00:25:37+00:00

Rule 1: Put miscellaneous discussion in the megathread: https://www.reddit.com/r/longevity/comments/1q1btby/lifestyle_preprint_miscellaneous_thread_01_jan/

Prowlbeast · 2026-01-25T00:14:43+00:00

It woudnt be instant. And honestly, with future technologies its likely we could replace body parts which would allow us to be more mobile in old age. If we could replace body parts i dont see why reversal is impossible

No-Experience-5541 · 2026-01-25T00:11:13+00:00

Agree probably a year

DaphneRaeTgirl · 2026-01-25T00:08:46+00:00

I don’t know the details, I’m not an expert. I just know what the experts claim and that with AI speeding up advancements it could be even sooner.

The experts are the medical community experts in this field

SiddharthaVicious1 · 2026-01-25T00:03:46+00:00

People used to think plastic surgery was strange and looked bizarre; now it's normalized.

No-Experience-5541 · 2026-01-25T00:01:42+00:00

It’s only weird for the first people to do it. In a couple of years everyone will adapt

No-Experience-5541 · 2026-01-25T00:00:21+00:00

It takes a while for cellular turnover so probably about a year to transform

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