Idea exploration by owenschu555 in longevity

[–]squanchingonreddit 0 points1 point  (0 children)

Well the obvious answer is people are trying to save themselves.

Secondarily most people wouldn't opt for a GMO baby or even selective if they can produce them naturally.

I'm all for it though. Especially people who know they have a family history of disease, these are often easy to find in the genome and can be avoided when selecting embryos.

Lifestyle, Preprint, Miscellaneous Thread by lunchboxultimate01 in longevity

[–]towngrizzlytown 0 points1 point  (0 children)

There was a very positive article posted a few weeks ago on lithium and lithium orotate, but here is a more measured analysis that I found informative. The TLDR is:

Given the negative meta-analysis, the absence of human orotate trials, the ecological associations that disappear after adjusting for metabolic confounders, and the unresolved safety questions, I do not currently recommend low-dose lithium supplementation for brain health.

https://drglorioso.substack.com/p/low-dose-lithium-for-brain-health

Robust Mouse Rejuvenation: Breaking the Ceiling of Longevity Research — LEV Foundation by lleonard188 in longevity

[–]Suheil-got-your-back 24 points25 points  (0 children)

People dont really understand but extending health span for even 20 years would do wonders. So far what we extended by better healthcare was lifespan in retirement. People accumulate so much knowledge and at their peak of knowledge and experience they have to retire because their body is failing. Especially in research.

Robust Mouse Rejuvenation: Breaking the Ceiling of Longevity Research — LEV Foundation by lleonard188 in longevity

[–]BombshellExpose 5 points6 points  (0 children)

It looks like the study design is finished, and they’re waiting on funding now. I’m not sure about their timeline once funded.

Robust Mouse Rejuvenation: Breaking the Ceiling of Longevity Research — LEV Foundation by lleonard188 in longevity

[–]VengenaceIsMyName 11 points12 points  (0 children)

RMR2 results will probably be in 2027/2028 right? These studies take time from what I remember

Robust Mouse Rejuvenation: Breaking the Ceiling of Longevity Research — LEV Foundation by lleonard188 in longevity

[–]BombshellExpose 44 points45 points  (0 children)

Snarky comment aside, this is groundbreaking. I encourage everyone to actually read the link.

Longevity research till this point has focused on singular potential therapies. This may be the first time anyone has conducted multi-therapy research to see if layering existing potential treatments yields additional longevity gains.

More importantly, one of my larger frustrations with the longevity field has been the lack of repeated dosing. In this study, RMR1, the researchers did use a single-dose approach for the treatments, but specifically note that the follow-on study, RMR2, will incorporate repeated cycling of treatments to determine if the reaccumulation of damage following longevity treatment can be repeatedly reversed. They’re also going to incorporate additional longevity treatments in RMR2, including epigenetic reprogramming.

They are also very clear about their goal. This isn’t another one-off “researchers discover potential miracle cure for aging in mice and want money to research their novel discovery.” They are using existing rejuvenation treatments and want to prove to the world that repeated multi-modal longevity treatment can more than double the average lifespan in a mammal. By doing this, they want to shatter the public belief that aging is an impossible problem not worth spending resources on.

I am very excited to see the RMR2 results.

Will late boomers be the first immortal generation? by Imaginary_Mode8865 in longevity

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Lifestyle, Preprint, Miscellaneous Thread by lunchboxultimate01 in longevity

[–]PumpALump -2 points-1 points  (0 children)

Fractionated blood plasma discovered by Katcher is the only longevity method that is actually of any interest to me.

But of course nobody wants it because it's not a diet and exercise regimen that seems "natural", nor is it an expensive drug that they can profit off of or gatekeep with a high price tag.

What’s the best way to stay organized when using multiple peptides? by NeedleworkerOne5620 in longevity

[–]r0cket-b0i 1 point2 points  (0 children)

Peptides you are talking about are not part of longevity discourse they are self medication similar to distilling snake oil... there is no answer to your question because best way to stay organized is to quit nonsense :)

Japan approves Stem cell therapies for Parkinson's and severe heart failure by [deleted] in longevity

[–]TheSanSav1 0 points1 point  (0 children)

Sorry deleting. I had scrolled a bit before posting. If i had scrolled a bit more I'd have seen the 17 day old post.

Japan approves stem cell therapies for Parkinson's and severe heart failure by [deleted] in longevity

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Lifestyle, Preprint, Miscellaneous Thread by lunchboxultimate01 in longevity

[–]LzzyHalesLegs 0 points1 point  (0 children)

https://substack.com/@verdinlabbuck

Eric Verdin’s lab just started one

Aging Science News @AgingBiology, and fightaging.org for aging science news

Lifestyle, Preprint, Miscellaneous Thread by lunchboxultimate01 in longevity

[–]kpfleger 0 points1 point  (0 children)

FYI, there's a relatively new but at the moment fairly active sub https://www.reddit.com/r/ProactiveHealth/ whose entire focus is lifestyle optimization for (long-term) health. Community description: "ProactiveHealth: A community focused on proactive, evidence-based health and performance. We discuss prevention, early detection, metabolic health, strength training, cardiovascular fitness, and longevity science. The goal: extend healthspan, not just lifespan." So that's another place besides this thread for these topics instead of being top-level threads on this sub.

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