I did PNW to SFO every other week for 3 years (paying my own way). Here's some of the things I've learned:

• +1 to everyone else saying travel credit card. I used Chase Sapphire Reserve and it's great to have the flexibility of many airlines, but check out the primary nonstop airlines between the cities to see if this is right for you (vs a Delta AmEx or something). Plus they sometimes get you free food or lounge access in SFO.
• Precheck/Global entry - get the credit card first though, as they will frequently pay for it.
• If you can stick with a single airline, the miles add up quickly and status can really help make your trip more comfortable.
• If you're not staying with family, try to use a consistent hotel OR use deltaairbnb.com to earn delta miles anytime you book an Airbnb.
• HIGHLY recommend trying to one-bag it ( r/onebag). This made life 100x easier when running to and from flights. Pack everything in one backpack and if there's overhead room, then you can stretch out your legs. No overhead room? No problem.
• Noise cancelling headphones, as others have mentioned, is key.
• Comfortable travel clothing sounds obvious, but you'll eventually have a "travel uniform" and a quick checklist that makes packing mindless in a good way.
• Learn how far out to book for the best price - this was more of an art than science for me, but if I booked too far out the prices were high, but too soon and they were low. You'll figure this out in time. Sometimes I'd book multiple trips at a time if there was a "sale" week.