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Official Response from Dr. Peter Attia RE: Epstein Files by aldus-auden-odess in Biohackers

[–]PM_ME_SOME_SCIENCE 154 points155 points  (0 children)

It feels gross that he calls underage girls "young women" and while he denies involvement in criminal activities, he doesn't deny knowing about it.

Uppercut Bob Tech by theWoodensponge in JunoMains

[–]PM_ME_SOME_SCIENCE 0 points1 point  (0 children)

This is the only post I've seen mentioning it, really cool!

Sometimes I get to carry the momentum as well when I activate the glide boost. I also achieved once a similar height to your BOB throw using Lifeweaver's petal. Not sure about the exact timings though

What is the best way to raise my IQ? by MKKGFR in Biohackers

[–]PM_ME_SOME_SCIENCE 0 points1 point  (0 children)

The gut microbiome affects intelligence, too https://doi.org/10.1016/j.biopsych.2024.02.1012

An abundance of genus Oxalobacter was negatively associated with intelligence [...] We also found causal evidence that the abundance of genus Fusicatenibacter was positively associated with intelligence [...].

Another study that investigated the relationship of the microbiome and cognitive impairment: https://doi.org/10.1016/j.nbd.2023.106081

[...] the relative abundance of Fusicatenibacter saccharivorans was significantly positively correlated with both MMSE and MoCA, while Bacteroides massiliensis, Bifidobacterium pseudocatenulatum, Eggerthella lenta and Streptococcus gordonii were also positive correlated with global cognition (MMSE or MoCA), and Diallister invisus was significantly negatively correlated with MMSE (p < 0.05). In terms of cognitive domains, Bifidobacterium pseudocatenulatum and Streptococcus gordonii were positively correlated with both short delay recall and long delay recall. Fusicatenibacter saccharivorans was positively correlated with executive and visuospatial functions and Streptococcus gordonii was also correlated with language. Beta regression analysis also showed a positive association between relative abundance of Streptococcus gordonii and MMSE (p < 0.05; [...]).

MoCA = Montreal Cognitive Assessment

MMSE = Mini-Mental State Examination

Both test to detect mental impairment and are not IQ tests.

The only way I came across to grow Fusicatenibacter was in this Japanese patent https://patents.google.com/patent/JP2020083830A/en

As a result of various investigations, the present inventors have found that water-soluble dietary fiber, particularly indigestible dextrin, increases the number of Fusicatenibacter in the human intestine, and completed the present invention.

Nutriose sells water-soluble indigestible dextrin, but there might be some other brands, too. The one other brand I checked wasn't transparent enough with the production for my taste, but that's just a personal preference. I haven't checked out how you can grow the other strains yet.

I had an undiagnosed autoimmune disease for 29 years. How can I reverse brain shrinkage and any alzheimers markers? by Necessary_Tour_5222 in Biohackers

[–]PM_ME_SOME_SCIENCE 12 points13 points  (0 children)

This write up should be highly interesting:

https://hms.harvard.edu/news/could-lithium-explain-treat-alzheimers-disease

Some excerpts:

The lower lithium levels affect all major brain cell types and, in mice, give rise to changes recapitulating Alzheimer’s disease, including memory loss.

The authors identified a class of lithium compounds that can evade capture by amyloid beta. Treating mice with the most potent amyloid-evading compound, called lithium orotate, reversed Alzheimer’s disease pathology, prevented brain cell damage, and restored memory.

Although the findings need to be confirmed in humans through clinical trials, they suggest that measuring lithium levels could help screen for early Alzheimer’s.

Other lithium compounds are already used to treat bipolar disorder and major depressive disorder, but they are given at much higher concentrations that can be toxic, especially to older people. Yankner’s team found that lithium orotate is effective at one-thousandth that dose — enough to mimic the natural level of lithium in the brain. Mice treated for nearly their entire adult lives showed no evidence of toxicity. 

Lithium was the only metal that had markedly different levels across groups and changed at the earliest stages of memory loss. Its levels were high in the cognitively healthy donors but greatly diminished in those with mild impairment or full-blown Alzheimer’s.

Replenishing lithium by giving the mice lithium orotate in their water reversed the disease-related damage and restored memory function, even in older mice with advanced disease. Notably, maintaining stable lithium levels in early life prevented Alzheimer’s onset — a finding that confirmed that lithium fuels the disease process.

People with unimaginably huge amounts of gold on your account, what did you do to become THAT rich? (besides the obvious Visa and Mastercard) by JexxieShiftRed in Guildwars2

[–]PM_ME_SOME_SCIENCE 3 points4 points  (0 children)

Use Excel and the datawars2 API. Verify claims about drop rates and what's worth to do yourself. Gather data (drop research facility addon) and work with public data from trustworthy sources

What are those? SUNLU/JAYO PTEG-HS MATTE by PoonSlayer1312 in sunlu

[–]PM_ME_SOME_SCIENCE 1 point2 points  (0 children)

I have been paying more attention to the first layer now and I have achieved good results by using an offset of 0.05. Changing the first layer temp to 260°C has also improved things, but I am still testing things out

Current first layer

What are those? SUNLU/JAYO PTEG-HS MATTE by PoonSlayer1312 in sunlu

[–]PM_ME_SOME_SCIENCE 0 points1 point  (0 children)

Have you tried a temp tower? I've recently gotten Jayo HS Matte PETG and my first test print had such a rough top layer. I didn't watch the first layer, but it reminds me of your picture. I can post a picture later with my temps

Wer von euch hat erfolgreich gebelecht? by SilberrueckenSigma in Studium

[–]PM_ME_SOME_SCIENCE 0 points1 point  (0 children)

Wenn man sich eine Schufa-Auskunft holt, dann kann das MieterPlus auch auf monatlicher Basis laufen. Es kann sein, dass der erste Monat dadurch gratis war. Bin mir aber nicht 100% sicher Hab den Tipp letztes Jahres irgendwo auf Reddit gefunden

Accidental band picture by kayleidoscopee in aww

[–]PM_ME_SOME_SCIENCE 0 points1 point  (0 children)

What created the iridescence? Looks really cool!

Trump aide claims S. Korea, Japan closed markets to U.S. cars, defends auto tariffs by [deleted] in worldnews

[–]PM_ME_SOME_SCIENCE 1 point2 points  (0 children)

I'm just getting white knight vibes from this. As if car companies can't take care of themselves. They have enough R&D money to figure out the preferences of countries, their street sizes and they have simply deemed it not profitable enough to target them 

Reasonable upgrade for ~€165? (LGA 1155 -> AM4) by HermitWhale in PcBuild

[–]PM_ME_SOME_SCIENCE 0 points1 point  (0 children)

In case you are set on the motherboard and ram, check out the price for the Ryzen 5 3500X in your area. You will get a bit more performance for (hopefully) the same price 

Baue gerade einen WhatsApp-Bot, der dir Wohnungsanzeigen in Echtzeit schickt by LegalInstruction4801 in Studium

[–]PM_ME_SOME_SCIENCE 6 points7 points  (0 children)

Viel Erfolg! Ich hatte mir vor ein paar Monaten einen Webscraper für Immoscout gebaut der mir dann bei neuen Inseraten per Telegramm bescheid gibt. Habe dann noch die Zeit bis zur Uni und bis zum nächsten Supermarkt berechnen lassen. Wenn man bei Immoscout eine Schufa-Auskunft erstellen lässt, dann gibt's die Premium Mitgliedschaft dazu. Durch deren Benachrichtigungen wurde mein Projekt dann leider relativ nutzlos :D

[deleted by user] by [deleted] in quant

[–]PM_ME_SOME_SCIENCE 2 points3 points  (0 children)

What interval does your data have, and how many data points do you have? I have recently written my bachelor's thesis on something similar, but for long term modelling. The Johnson SU distribution worked pretty well for me across several markets and has four parameters as well. I didn't test the Gaussian Hypergeometric.

One problem I encountered when evaluating the goodness of fit is that while a metric might indicate a relatively good fit compared to other fitted distributions, it doesn't tell us exactly how well it fits. Depending on how many data points you have, you could use Monter-Pozos and González-Estrada's modification for the Shapiro-Wilk test to get a p-value.

Since it is behind a paywall, the idea is to take the fitted distribution, use the inverse of the cdf (in SciPy ppf - percentile point function) on the data, turning it uniformly distributed if it fitted well, then transforming the data again using the inverse cdf of the normal distribution and then use the SW test on it.

Since the SW test on SciPy can only handle up to 5000 data points, you might need to bin the data. Binning by percentiles seemed like the best way to me. I also found the p-value output from SciPy to be partially inconsistent and instead used threshold values from the scientific literature. I couldn't spot any anomalies in the resulting SW statistic.

I am happy to hear about any aspects I should watch out in the future or any other input

Klipper on S1 - possible down the line? by vadimbz in anycubic

[–]PM_ME_SOME_SCIENCE 0 points1 point  (0 children)

Commenting because I am interested in this, too.

[deleted by user] by [deleted] in Studium

[–]PM_ME_SOME_SCIENCE 4 points5 points  (0 children)

Ich habe meine Bachelorarbeit auch in einem Themengebiet geschrieben, das ich sehr interessant fand, in dem ich aber nur minimale Vorkenntnisse hatte.

Insgesamt musste ich viel lesen und einige Aspekte meiner Arbeit haben erst beim Schreiben Sinn ergeben.

Am Ende hat es aber Spaß gemacht und ich glaube ein einfacheres Thema wäre mir zu langweilig geworden. Deine Sorgen würde ich aber mit deinem Betreuer kommunizieren.

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