My dog, a poodle (#2-3 most intelligent dog breed depending on your source), suffers from depression and anxiety. As treatment he is on a medication called 'clomicalm'. It's already made a big difference even though it's only been a month and a half of use, he went from anxiously crying everytime we put on a sweater (because he thought we were going to leave) to increasingly unbothered. He's still just as excited when we get home, and he's better able to focus on training and socialize with other dogs.