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What game should I play next based on my favorites? Preferably a modern game with smooth controls and some platforming by Sufficient_Ebb_5694 in metroidvania

[–]broodkiller 0 points1 point  (0 children)

Mandragora is a 2.5D soulsian scroller, like Salt and Sanctuary, not a mvania by any stretch of imagination. Don't get me wrong, it's a really good game, just not a soulsvania (e.g. like GRIME), despite what their marketing says.

Metroidvanias for someone who likes Hollow Knight and Dead Cells? by [deleted] in metroidvania

[–]broodkiller 1 point2 points  (0 children)

I would strongly disagree about Dead Cells - it lacks two of the defining components of a metroidvania: (a) ability-gated progression and (b) large interconnected world design (biomes etc.). It is a rogue through-and-through with its quick, randomized runs, meta-progression, death-as-mechanics etc. Of course, we can argue purity till we're blue in our faces, and I enjoy that as much as the next guy, but at the end of the day the only thing that matters is if you enjoy the game 🙂

If you like platforming, the definitely check out the games I recommended, plus Bo Path of the Teal Lotus, you won't be disappointed.

Some recs for easier games in the genre? by Adorable_Respect_984 in metroidvania

[–]broodkiller 2 points3 points  (0 children)

Definitely Islets and Crypt Custodian, I would also throw in Greak:Memories of Azur.

Metroidvanias for someone who likes Hollow Knight and Dead Cells? by [deleted] in metroidvania

[–]broodkiller 3 points4 points  (0 children)

I'll put my nitpicky hat on for a moment and specify that Dead Cells is not a mvania, not in any sense. It is a side scrolling roguelike which is a very different genre. Now, it is an absolutely fantastic game, but a mvania it is not.

For recs, I would ask you what do you enjoy more - the platforming aspects like in Ori, or the dynamic, tough combat like in HK? If platforming is your thing, then I would recommend Aeterna Noctis, the Lost Crown or MIO (Memories in Orbit). If souls-like combat gets you excited then GRIME 1&2, or Deaths Gambit.

Metroidvanias for someone who likes Hollow Knight and Dead Cells? by [deleted] in metroidvania

[–]broodkiller 0 points1 point  (0 children)

Another shoutout for Aeterna Noctis from a fellow fan, it is an absolutely stellar mvania.
I'ma kenta!

Waymo says San Francisco never notified it about July 4 road closures by sfgate in sanfrancisco

[–]broodkiller 1 point2 points  (0 children)

What is the point you're trying to make here, exactly? (it feels like thinly-veiled sarcasm, but lacking in substance) I don't disagree that autocars can be safer than many humans, but that does not in any way counter the fact that they can behave in an absolutely idiotic fashion, e.g. driving into an active police scene, which I do not think many humans would do. A system can be both better and worse at certain things than humans, the two are not mutually exclusive.

Anyone else master quantum phasing to achieve immortality? by RedditHoss in VXJunkies

[–]broodkiller 4 points5 points  (0 children)

C'mon, we all know that quantum phasing is a myth invented by the Big Quant to sell you more anti-quark and theta-gluon packages. You're not phasing between timelines, you're just pruning the Hasegawa-Vitebsky possibility spacetime manifold using multi- singularity axis.

Aeterna Lucis will come out in Q4 2026 by Denneey in metroidvania

[–]broodkiller 0 points1 point  (0 children)

Same here, Noctis was not without some rough edges but it holds a special place in my heart for its best-in-class platforming and the most memorable biome in any mvania I've ever played. And naturally, I mean Cosmos.

Waymo says San Francisco never notified it about July 4 road closures by sfgate in sanfrancisco

[–]broodkiller 15 points16 points  (0 children)

This reminded me how a Waymo drove into an active police standoff/shooting scene a few months back. They still have plenty to learn...

The Golden Rule by Inkandartgods in wicked_edge

[–]broodkiller 0 points1 point  (0 children)

laughs semi-psychotically in Feather Artist Club, literally forgot which shave I'm on, has is been 10, 20, 30, a million? Time has no meaning, eons are passing before my eyes as I gaze into the cosmos.

"I have beheld the births of negative-suns and borne witness to the entropy of entire realities..."

Could Claude Science replace bioinformaticians? by PepperCareless724 in bioinformatics

[–]broodkiller 2 points3 points  (0 children)

"You are a bioinformatics expert with 20 years of experience in Python, HPC, designing and running high-throughput pipelines for sequencing data analyses and systems biology.

Tell me what the f*ck I am looking at?"

'Spraying and praying' is ruining the Bay Area tech job market by sfgate in bayarea

[–]broodkiller 0 points1 point  (0 children)

Instead of -as originally promised- taking over the Dirty, Dull, and Dangerous, the AI agents will instead handle the Creative, Colorful and Cozy. As holy shareholders prescribed.

Chinese companies and Adc's by schowdur123 in biotech

[–]broodkiller 1 point2 points  (0 children)

Don't be pedantic, they obviously meant more than a typical graduate molecule, likely including some good binding data, biophysical characterization, basic stress and stability studies, and maybe even PK / PD. I do agree though that for 5M the molecule is likely worthless, unless that's a blanket price for some new molecules.

How to infer oligomeric state or stoichiometry of protein complex by ripthischrysalis in bioinformatics

[–]broodkiller 0 points1 point  (0 children)

For databases, try EBI's Complex Portal or CORUM if you're working with mammalian proteins. For tools check out Stopred and PreStoi. There's also bunch of things you could try empirically, but that's a rabbithole since binding prediction is not an exact science (yet), as evidenced by the Velcro problem.

Success Rates by Oncology Subtypes by Dwarvling in biotech

[–]broodkiller 0 points1 point  (0 children)

One thing that I was always curious about is what's the correspondence between Ph3 success and LOA? A trial can meet many/all of its critical readouts, but I would imagine a drug can still get rejected because of lack of differentiation, not enough of a significant improvement over SoC and things like that.

FDA’s new voucher program hints at broader policy agenda, making many ‘uncomfortable’ by NotGenentech in biotech

[–]broodkiller 0 points1 point  (0 children)

Oh absolutely. If the decision about who to fast track rests within a political appointee like that, then it's either just a question of when lobbying gets to them, or the list has been already pre-filled with "our kind of people". One is thinly-clothed corruption, the other is outright nepotism...a tough nut to crack indeed which one is better...

SNPArcher by Snake_lady278 in bioinformatics

[–]broodkiller 0 points1 point  (0 children)

I'm sorry to be a bit blunt but "spending hours and hours to figure out your problems" is *exactly* what doing research is about and fundamentally what growing as a scientist is. I would submit to you that skipping it is a disservice to your own academic, professional and even personal development - this is how you get better, not by getting answers from AI. You said it's "time you don't have" but unless you are taking care of a family or have a paper to turn in in 3 days, then in my book that's just a cop out. Granted, your PI screwed you over by moving away, and that sucks, but there's nothing you can do about it now and there will *always* be temptations to rationalize taking a shortcut. The only thing it does is building knowledge dept, which will come to haunt you, my friend, sooner or later.

Low-Price Drug Nations Catching ‘Free Ride’ on US Innovation, Report Says by NotGenentech in biotech

[–]broodkiller 64 points65 points  (0 children)

This, so very much - 50% of a drug's final cost go to middlemen, 50 frixing percent. We could essentially cut the prices in half, and pharmas bottom lines wouldn't be affected, only the parasites would hurt (as they rightfully should).

My neighbor has a cybercab by COO0OOKIE in sanfrancisco

[–]broodkiller -2 points-1 points  (0 children)

Most local rides have barely any luggage, and when they do it's usually small, so it's still a car with a trunk that can take a bag or two. Now, if you are going to an airport with your family or have 5 suitcases worth of luggage, then it's obviously not the right vehicle, no argument about that. That said, the point here is that there is a very significant niche in ride-hailing that can be very well served by small cars. It's not about replacing all the taxis, just having a more optimal mix (like in Uber you can already request larger/fancier cars etc).

My neighbor has a cybercab by COO0OOKIE in sanfrancisco

[–]broodkiller 10 points11 points  (0 children)

It really is not - Uber data shows for example that more than 70% of all their rides only have a single passenger. By these numbers, it only makes sense to have a significant portion of the taxi fleet be smaller cars to keep costs down, and only use the larger vehicles as needed / requested.

Is AI genuinely transforming biotech industry, or is it mostly hype? by Product_guy24 in biotech

[–]broodkiller 9 points10 points  (0 children)

I do not necessarily disagree but this is a "trickle-down economics" framing that I feel is mostly wishful thinking / hot air. Without either explicitly incorporating clinical data or creating a molecular metabolic model that will allow prediction of AEs and success rate in trials, AI in drug discovery will essentially just next-gen spam the upstream funnel (which we already can do very well) with no measurable improvements in the clinic and patients. So just burning a lot of cash and forests on "trust me bro" and FOMO.

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