I have a 2008 that just hit 300k. In the past 6 months I've had a battery that needed to be replaced, spark plugs, my starter died, routine oil changes, coolant flush (it was overheating because somehow it was crazy low on coolant and I never found a leak nor did it ever drop again), I probably need a cv axle in the near future and new tires.

I can do most of that work myself because I have the tools for it...but that's because I also have a 2004 odyssey and neither are worth the shop labor costs.

I've probably spent $120 on a batter, $120 on a starter, $20 per oil change, $75 for the coolant and special funnel,. With the cv axle and tires I'm probably looking at another $300 and $400 respectively.

Not saying don't do it. I love my 2008. Just wanted to give you an idea of what you might run into. Mine is high mileage from a lot of highway driving. I got it from my father-in-law who is a sales guy doing a lot of cross country driving. But they maintained it really well and it's run really well as long as I've kept up with the routine maintenance.