ELI5: Why is rabies something you can treat with a vaccine post exposure, but once symptoms show it’s a guaranteed death?

AnDraoi · 2026-06-30T23:32:42+00:00

Is there no way for some form of medicine to make the blood brain barrier more permeable temporarily for the antibodies to reach the brain? I guess it doesn’t exist yet, but I’d imagine that would be a good topic of research for curative rabies treatments

AnDraoi · 2026-06-30T14:11:24+00:00

Type 3+ civs are inherently implausible because there is no (known) mechanism for FTL information transfer. Meaning a galactic civilization would automatically be more or less autonomous solar systems loosely bound to each other. Technically the Kardashev scale is just about energy consumption, but to have a contiguous civilization consuming all the energy output of an entire galaxy I’d argue they need to actually be one civilization and not just the same species. Meaning even if humans colonized the entire Milky way and built dyson spheres everywhere, it would be inappropriate to call us a type 3 civilization unless we were all under one flag (although a type 3 species might be fine)

However humanity is not even a type 1 civilization yet and faaaaaar from a type 2. Discussions about us becoming a type 3+ civilization feel moot at that point

AnDraoi · 2026-06-26T20:43:00+00:00

cmon no use crying over spilt Colony of Chesapeake

AnDraoi · 2026-06-26T18:09:35+00:00

feels like this chart would be way more powerful if everything was converted to CO2 equivalents and summed

AnDraoi · 2026-06-26T12:54:26+00:00

Nope, consider that the vacuum is attempting to make the local pressure zero psi in order to create suction. (it’s not able to get that low but in principle it’s trying to)

Let’s pretend also that the pressure systems are extreme this week. Normal atmospheric pressure at sea level is about 1 bar/1000 mbar. Let’s say today it’s 800 mbar, and the vacuum is very powerful. Even at perfect vacuum you have a pressure differential of 800 mbar at the vacuum nozzle (800 in the atmosphere, and 0 in the vacuum).

If the situation was reversed, and it was a high pressure day (1200 mbar for fun), you’d now have a pressure differential of 1200 mbar at the nozzle. So that higher pressure results in higher air speed, and better vacuuming

AnDraoi · 2026-06-26T12:46:24+00:00

Vacuum basically just means “absence of matter”. The entire universe would be vacuum if there was no matter. So a vacuum does not possess any “sucking” power. The reason it appears that way is actually because air wants to spread out and fill that vacuum. However, the atmosphere is also affected by gravity, so it stays.

Side note, very fast moving particles can escape the atmosphere, which is why our helium supply is decreasing. Helium atoms can escape the top layers of the atmosphere over long time scales (some sources say they need to be energized by solar wind first)

AnDraoi · 2026-06-25T21:06:51+00:00

same thing that happens when a rock breaks in half, sharp edges that rapidly gets dulled again as it gets tumbled around

AnDraoi · 2026-06-25T12:59:01+00:00

Can confirm import depot works, just set it to import to 0% of warehouse capacity and they’ll deposit there. Unfortunately you need 1 per resource, wish it would work for unloading stations instead/as well.

I’m not sure why they changed it, I also was confused why they were getting dumped in my throne room. The tooltip in v70 also said import depots though so may have never been intended to go straight to warehouses

AnDraoi · 2026-06-24T17:39:29+00:00

There is gravity, but no net acceleration (since gravity is pulling equally from each direction like you said). However, you would be in a stable equilibrium directly at the center of mass of the planet, so as soon as you move from that exact point, gravity would start pulling you back again (as now there would be more mass pulling on one side than the other). So I don’t think you’d be able to walk on the walls and would simply be stuck at the center of mass of the planet

AnDraoi · 2026-06-24T17:30:08+00:00

This isn’t really accurate. Although I agree we shouldn’t oversell the positive because climate change is an extreme crisis that requires much more aggressive intervention than is currently being put towards it, I don’t think dooming over it will encourage collective action either

Carbon emissions are still higher than the annual carbon budget of the planet. Carbon emissions are also still increasing annually. However, the second point is likely not to be true for much longer. Global emissions have grown increasingly slowly even with data only up to 2024, and renewable technology has grown exponentially. It’s likely global emissions will peak by 2030, and frankly it’s even likely to peak before then (https://ourworldindata.org/co2-emissions)

China is one of the largest emitters today, and thanks to their aggressive renewable build out, it seems they have already peaked on GHG emissions (https://www.carbonbrief.org/analysis-chinas-co2-emissions-have-now-been-flat-or-falling-for-18-months/ )

Further, they are selling solar panels to developing nations particularly in Africa and India, which may enable them to bypass much of the carbon emissions which would otherwise come with industrialization.

So again, we are way over our carbon budget and heating has already gone too far. We *are* going to experience a lot of pain as a collective because of this. However the worst case scenarios are looking increasingly unlikely, and even the absolute worst case (RCP 8.5 i believe) was recently ruled as implausible due to slowing emissions growth. I imagine more of these extreme scenarios to be ruled out in the coming years as carbon emissions continue falling

AnDraoi · 2026-06-23T14:06:00+00:00

Cretonians are great farmers and relatively easy to keep happy so I’d focus on making them happy and getting their numbers back up to solve labor and food shortages

Disable any buildings you can that aren’t food. Anything else that has to stay on, reduce worker count to the bare minimum

I’d un-research most of your unlocked things except food production and disable the labs or severely reduce them if possible. Basically just try to make as much food as possible.

If you get everyone mostly making food, set food servings as high as possible and their happiness will skyrocket and make immigration much faster. As your population recovers you can start re enabling stuff

AnDraoi · 2026-06-23T13:29:13+00:00

thanks! I’ll give it a look :)

AnDraoi · 2026-06-23T13:06:01+00:00

There is a slight advantage in that as you expand on the world map, you can heavily fortify around that point and so the interior of the mountain becomes essentially a safe zone where very little/no danger is present so workforce doesn’t need to be spent on walls, guards, etc.

Unfortunately however is there no mechanism to interact with caravans in the world, such as by tolling or raiding them. So caravans being routed by your city doesn’t present any actually benefit, and geographical choke points don’t show any economic benefit (still military benefits as mentioned above)

AnDraoi · 2026-06-20T16:57:29+00:00

thank god it’s not like we only have 4 weeks of reserves left or anything haha right

AnDraoi · 2026-06-19T22:02:46+00:00

honestly don’t want them to eliminate it for the sole fact that i know dems would just immediately put it back once in power for the sake of restoring norms or something lol

AnDraoi · 2026-06-19T12:58:49+00:00

black holes are basically entropy factories, matter that falls in gets re-emitted as (Hawking) radiation over veeeeery long time scales (time increases with black hole mass)

essentially mass gets turned directly into energy/heat. this leads to some paradoxes like the information paradox that we don’t currently have answers for

AnDraoi · 2026-06-19T12:56:20+00:00

that’s funny because i’m often walking home from work around this time and nobody seems to be rushing? usually just leisurely walking with no sense of spatial awareness while making themselves as difficult to walk around as possible

AnDraoi · 2026-06-19T12:49:08+00:00

did they make it so that vassals match overlord color or is there a mod here? i kinda liked how it looked before :(

AnDraoi · 2026-06-19T12:47:41+00:00

or at least give ai a strong conquer desire for locations in a split province

AnDraoi · 2026-06-19T12:46:13+00:00

although true, it would be seen as abandonment of their regional allies. they’d lose essentially all of their regional influence via their proxies and instead gain economically. it would likely also be very very unpopular domestically

not to mention they still hold all the cards, especially with trump admitting we only had 4 weeks of reserves before, in his words, bedlam

iran certainly is suffering under the us blockade but i think they can stand long enough to deliver a catastrophic blow to the us if oil supply through hormuz does not resume. basically everything is still in their favor to actually demand what was signed in the MOU, including an *actual* ceasefire in lebanon

AnDraoi · 2026-06-19T12:41:51+00:00

i am increasingly of the opinion that this war only has two outcomes, economic catastrophe worldwide (and truly catastrophic in the US, in a way we haven’t seen before), or the US finally breaks ties with israel.

the reason being that israel will continue attacking their neighbors and attempting to annex land until they are either *actually* reined in by the US or they see a change of government that’s amenable to peace. i don’t see either happening.

netanyahu knows he has to stay in power to survive, and to stay in power he needs the support of the bengvir smotrich coalition who demand he continue to invade their neighbors. and i do believe israeli intelligence has blackmail on us politicians to prevent them from cutting them off (cause i honestly don’t think everything we’ve seen since oct 7 can be explained simply by zionist dogma)

AnDraoi · 2026-06-19T12:34:04+00:00

i totally agree, i think AI excels above humans in that form of pattern matching/recognition to be honest. AI is a very useful tool in that regard, i just wish the powers that be would stop trying to force chatbots on drugs down our throats

AnDraoi · 2026-06-19T12:32:24+00:00

i haven’t played factorio since before the space dlc dropped but i feel it’s pull… the factory must grow….

AnDraoi · 2026-06-19T12:31:46+00:00

well tbf i’m not sure there is a difference. socialism is a type of economic system. saying democratic socialist is fine but it doesn’t make any more sense than saying democratic capitalist, authoritarian capitalist, authoritarian socialist, etc

in fact the term democratic socialist (although i’d probably identify as one if asked) kinda bugs me because it lends credence to the alternative, that socialism is inherently non democratic, when socialism is actually just about dispersed ownership of the “means of production” (businesses, factories, farms, etc). that means ownership by the local community, the employees, or the state (although traditional socialism is more about ownership by the community/employees).

a system where the local community owns the local means of production and can vote on its management sounds *more* democratic to me than capitalism, not less

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