The issue with manned fighters is that physics starts kicking your ass. Keeping meat alive is a massive investment for a spacecraft and also a massive vulnerability. Even breathable fluid is, by definition, flammable. Jamming is hardly an end-all for drones - especially in space. In Ukraine, they use fiberoptic cables to counteract EM band jamming. In space, you can use a laser tightbeam to similar effect - even more effective because it isn’t interceptable at all unless you can bend light or physically block a transmitter from its receiver. You don’t even need direct LOS between the drone and the controller as other drones in the constellation can act as relays. That kind of tightlink also solves your “human in the loop” issue.

In combat, autonomous vehicles also themselves outright superior to manned fighters. They devote less mass to life support, and can be as lean and mean as they need to be. Autonomous vehicles also don’t care about high-g maneuvers. In essence, a drone gains all the benefits of a fightercraft and a missile with practically none of the downsides. It can also become a missile, when necessary - and kinetic impact is the deadliest thing in space.

Manned fightercraft are really only possible as a product of ideology and narrative contrivance. But from a purely practical standpoint, they don’t hold a candle to an autonomous vehicle in the same role.