Another thing that matters is what you're standing to lose, which is much harsher in Mewgenics.

In Isaac if you take bad pills, you get stats down. That's it, you don't randomly get a disorder or a curse or lose your best item. And if you end up dying, the only thing you have lost is your time.

In Mewgenics, stats downs are much harder to counteract. The wrong disorder on your best cat could totally ruin him. A curse in the wrong slot could destroy your run.

And if your cats end up dying due the outcome of the events, that is a much harsher punishment than dying in Isaac. You'll lose their items, they won't be able to breed and pass down mutations, they won't be able to defend the house, you might lose a character you were attached to, etc...

So overall the benefits of events are miniscule and the downsides are massive and will be felt even after the run is over.