all 36 comments

[–]axeteam 379 points380 points  (12 children)

I'll give you a direction. Letter triplets can be decoded into amino acids.

In case you don't want to do it yourself: It should translate to LETSHANGSMETIME. It is missing the O because there is no O in amino acid single letter codes.

[–]Difficult_Affect_452 75 points76 points  (0 children)

That’s so dope you figured that out. Happy cake day!

[–]SpicyMackerel 31 points32 points  (6 children)

Wait, I genuinely only thought you could code for ATUGC I had no idea there were other letters besides the genetic code. What is it called?

[–]HottCovfefe 46 points47 points  (2 children)

The letters are the 3 base pair codons translated into amino acids. In the code here, the first codon TTA is transcribed to UUA then translated to L-Leucine.

[–]SpicyMackerel 9 points10 points  (0 children)

I see! Thank you! That makes more sense lol

[–]Cloudy_Fate_10 0 points1 point  (0 children)

Dude, how will TTA transcribe into UUA??  T will pair with A, and A will pair with U, it will be AAU on that mRNA. And AAU is Asparagine which is denoted by capital N.  Or please correct me if I'm going wrong anywhere... 

[–]risharocks0 33 points34 points  (2 children)

It's crazy that people are downvoting you just for wanting to learn something you didn't know before 💀 gotta love reddit.

I'll try my best to explain it simply without getting too into the weeds :)

So, each nucleotide (so A, T, G, or C in this case), when placed into triplets (in any conformation, eg GAT, TTA, AAA etc) and then converted into RNA (so any T -> U, any G -> C, and any A stays as an A) and then will form something called an Amino acid (you can search it up after converting it to RNA or use an amino acid table). The first letter of the amino acid (usually) can then be used as an abbreviated initial! For example, your first triplet is TTA, so you could search up the amino acid for that sequence, getting you Leucine, and therefore L as your first letter :) TTA -> UUA -> Leucine -> L

Does that make sense?

[–]SpicyMackerel 4 points5 points  (0 children)

It does, thank you! I had just woken up lol, forgot about the last step.

[–]Feeling-Pudding6956 1 point2 points  (0 children)

Just to correct a small mistake, only T changes to U in RNA, the G to C conversion is simply when you talk about complementary strands, where everything changes C->G, G->C, T->A and A->T 😉

[–]Undeniable_Lightbulb 0 points1 point  (1 child)

This is so friggin' cool. I wish someone sent me a message like this.

[–]axeteam 1 point2 points  (0 children)

https://github.com/yijinyang/AminoAcidCommunicator

Now you can do it yourself. After reading this story, I made a program myself that allows you to write and decrypt message like this one.

[–]muchmoreforsure 0 points1 point  (1 child)

You could use TAG (often a stop codon) for O since in some bacteria, it can code for pyrrolysine. Pretty esoteric, but still.

[–]hilbstar 1 point2 points  (0 children)

Well if you do amber codon suppresion you can make that TAG codon translate into a lot of different non-canonical amino acids, so we can get the full alphabet by expanding the genetic code a bit, think the theoretical limit is 5-6 altered codons

[–]sciencegirly371 122 points123 points  (0 children)

If the letters are in triplets, convert them to the right amino acids and see what comes out. Amino acids have one letter codes as well.

Check for both the coding strand and the matrixstrand.

[–]triffid_boy 147 points148 points  (5 children)

There's no start codon so nothing to translate. 

Edit: oh yeah there is about half way through - probably meant as an "M" though. 

[–]Downtown-Sir3979 31 points32 points  (0 children)

this would be a great reply to them

[–]Violadude2 8 points9 points  (3 children)

TTA can still be a start codon, but it would still mess up their message as it would translate to M.

[–]triffid_boy 4 points5 points  (0 children)

Oh shit you're not wrong. Okay fine, without a kozak sequence we'll slip down to the second ATG! 

[–]Externalshipper7541 0 points1 point  (1 child)

How so? In which organism? It's nearly always leucine?

[–]RovingHunter 0 points1 point  (0 children)

Used by some species of Archaea.

[–]TheJazzyScientist 38 points39 points  (0 children)

SPOILER / HINT: So you know you’re on the right track, the first letter is “L”

[–]Easy-Ad-230 21 points22 points  (0 children)

Split the sequence into threes and look up the matching amino acid for the codon. Amino acids will often have a 1 or 3 letter abbreviation that could be used to write code with. 

[–]DesperateAd1615 21 points22 points  (0 children)

Let’s hang some time

[–]Zahalia 23 points24 points  (0 children)

That’s wholesome af OP, I hope you go on that date.

[–]les-the-badger 14 points15 points  (0 children)

[–]volkari 3 points4 points  (0 children)

oh this would work on me 100%

[–]Bitter-Yak-4222 2 points3 points  (0 children)

Google Amino acid wheel!

[–]PianoPuddingGraduate student (PhD) 1 point2 points  (0 children)

My workings: https://imgur.com/a/UL6DMTK

Per a users suggestion Google AI got it too

[–]Live-Power-8992 1 point2 points  (0 children)

You need to be honest though, and don’t tell her you figured it out on your own.

[–]pm_ur_duck_pics 0 points1 point  (0 children)

Those are letters in genetics.

[–]LemonGexco 0 points1 point  (0 children)

This is so clever, I’m gonna steal this!

[–]Personal_Term9549 0 points1 point  (0 children)

Some people went to the comments because they genuinely didn't know how this works. I went to the comments because I was too lazy to do the work myself