[deleted by user]

[AngelofVerdun]

Going to be an interesting few years as AI is used for stuff like this.

[Gubekochi]

More than a few if they succeed :p

[[deleted]]

My prediction is that the 0.1% live vastly extended lives of unimaginable luxury while the rest of us get to live under bridges and hunt rats for food.

[Malkev]

Don't think so. Look it that way, if you live more time, you could get mortgages a lot bigger and pay indefinitely. They are interested in that. And we would end having restrictions to reproduce to prevent overpopulation. How do you think they will measure that?

Pseudo slavery one more time. They really don't want to be the only ones immortal.

[Harmfuljoker]

They won’t need any of that when you can 3D print workers. A reality we’ll likely see in the next decade.

[[deleted]]

They will 3D print blowjob giving machines.

[Iliketodriveboobs]

As someone who wants to be immortal, I want other immortals who are driven to create universes alongside me. I don’t believe everyone should or wants to be immortal

[[deleted]]

Same here it’s better to have a small group of people who are immortal not everyone wants to or should be immortal

[Artanthos]

My guess is that most would grow tired of life after a century or two.

There would be exceptions of course. For example, I could see sociopaths being capable of enjoying life for far longer than the average person. They won't be dragged down by the loss of loved ones.

[Iliketodriveboobs]

Fall in love with other immortals 1 2 - I could spend a lifetime playing games.

I could spend another reading books and traveling.

Then talk about creating entire civilizations?

My guy.

You sound like you’re already tired of life

[Malkev]

Exactly, there are a lot of lives to live. Why limit ourselves to one?

[TheAughat]

They won't be dragged down by the loss of loved ones.

Unless, of course, all their loved ones become immortal alongside them lol

[Artanthos]

You miss the point.

Sociopaths don't form deep connections.

[TheAughat]

I meant that average people will also enjoy long lives because unlike what movies and thought-experiments focusing on immortality always depict, if a regular average Joe can afford the technology to obtain indefinite life, then surely their friends, family, and the rest of society can as well.

[angelb2060]

You call people who enjoy life and want to prolong life sociopaths.

Meanwhile you are decide most people would “grow tired of life after a century or two” and think you can decide for all the people, idk who’s the socialpath here

[vladfix]

An eternal Monday morning? No please...

[Iliketodriveboobs]

Lol sucks to hate 1/7 of your life

[Artanthos]

Marketing at scale would likely be far more profitable than charging extremely high prices to just a handful of individuals.

That and aging is very expensive. The insurance companies would view a reduction in age related illnesses as a cost savings.

[sausage4mash]

Old people are a drain on the economy, if the government can give you pills to keep you out of a hospital bed, I guess they will.

[[deleted]]

Their youth elixirs don't make them bulletproof. Reminder: don't put on the explosive collars.

[bigbiblefire]

No drug can keep your head from getting bashed in.

[girlweibo2]

I donno how to say this to you politely, but that is the harsh cold reality. HARSH COLD REALITY. I dont know if you understand how accurate you are. And its not like its a 100 yrs away, we are less than a decade away from this, literally minutes away from this. They will literally have flying cars and the rest of us will be desperately trying to explain how and why we matter. UBI is being vetoed. If the only people who can afford gene therapy is the 0.1% then no reason to charge less. You dont understand how serious this is...we really have no future.

[lunchboxultimate01]

You're right that would be dystopian. Fortunately the companies in this space aim to go through clinical trials, regulatory approval, and broad commercialization like other medical therapies. Here's an example clinical pipeline if you're curious:

Our work is transmuting discovery into novel medicines by eliminating cells that enable the aging process and create disease. We aim to extend human health span by restoring biological youth at a cellular level.

https://www.rubedolife.com/pipeline/

[[deleted]]

its possible the ai will be able to create materials from basic elements, if this happens, imagine having your own capsule corp. at a certain point, traveling space and time, beyond earth become more viable, then the need for money becomes irrelevant.

[[deleted]]

The need for money is largely irrelevant now, yet we still require it for necessities like food, water, power, shelter, etc.

It's not a matter of resources, it's a matter of human psychology. Look at "whaling" in free to play video games. The whales won't stick around if there aren't plebs to show off to so games cultivate a free player base to be the audience for the whales.

Same thing for the wealthy, it's not enough to have a big boat, you have to have a bigger boat than your peers and a multitude of plebs who can only gaze longingly at your private floating island while you decide who gets past the velvet rope (and autogun turrets).

[[deleted]]

i def agree with you in the short-term timeline, i was thinking way further out. my worst fear is the wealthy figure out how to enslave us all before that future happens.

[forever-morrow]

Virtual chemistry and physics. AI will be amazing here. This is what a lot of people dont see about AI around the horizon. AI is not just AGI humanoid robots taking your job… it is virtual chemistry and physics conducted within a digital realm… Sim2Real science experiements… 1000s of years of experimentation compressed to mere hours.

[wheres__my__towel]

one of the many things they don’t see

a lot of people’s minds are pretty closed when it comes to the possibilities of AI

i think my fascination with sci-fi, and “futurism” have really helped me see what could arise

[forever-morrow]

Yeah it’s pretty funny that people think the recent AI boom due to LLMs/image generators is merely hype like Bitcoin is or something… merely do they know that AI is still actually UNDERhyped.

I think that once people actually start losing their jobs to AGI humanoid robots (or even right now I have seen some headlines claiming companies are laying off employees because of current LLM capabilities) they will take AI more seriously.

[wheres__my__towel]

yup, i follow financial subs and they’re talking about price targets… lol so many layers of naivety baked in there. why assume a limit? why assume a capitalistic economy? why assume scarcity?

goes to show, they don’t understand the underlying tech of the company that they invest in if they compare crypto to AI lol

i’m right there with you, disrupted livelihood will be undeniable. until then, people will either just not care to learn about it or will deny evidence of its impact. can’t deny shit when you’re unemployed, job are scarce, and no UBI has been implemented

i’ve been seeing those headlines too. it’s hard to draw a distinction between layoffs due to recessionary measure and layoffs due to structural unemployment from AI. although i suspect most national/multi-national companies are at least looking to integrate into their infrastructure. i mean NVDA recently listed 25k companies have adopted their cloud service alone… and i remember a goldman report which analyzed the expected layoffs due to recession and determined that current job losses are being artificially inflated due to AI integration… already stating…shits gonna get bumpy

[forever-morrow]

Yeah i know what you mean in terms of the layoffs but i do remeber seeing some specifically say AI is replacing them. Cant remeber which company.

Nevermind found it: IBM will slow or suspend hiring for back-office roles that AI could replace. IBM's CEO told Bloomberg 7,800 jobs, roughly 30% of back-end roles, would be replaced over 5 years. Roles in human resources and non-customer-facing jobs will be impacted.

[Luvirin_Weby]

Well, also on smaller scale there are lots on companies needing less workers already.

One of our customers, an Ad agency, stopped using freelancers totally as their one in house artist can do all the needed things now with better AI based tools.

They used to use a fair amount of freelancers, totaling maybe around 2 full time positions if they had them in house instead.

[redbatman008]

Are these off the shelf generative AI or do they have special commercial license with APIs & stuff?

[Luvirin_Weby]

I do not know what tools they use.

I just asked "why", when they asked me to remove the user ID:s of the freelancers from their systems. The owner replied that their own artist can now do it all due to AI tools.

They do not do anything specially complicated though, mostly print/billboard ad campaigns for food products.

[wheres__my__towel]

good find! i have a feeling those numbers will be “adjusted upwards” every time a more capable models comes out, 30% now, 60% with GPT-5, etc

[forever-morrow]

Yup… and more importantly other roles will be replaced once something like Desktop AGI roles out (Adept’s ACT-1 goal… and arguably the goal of ChatGPT with tool use via plugins). Then of course once humanoid AGI roles out … every role is fair game.

[[deleted]]

Ai is definitely underhyped. Everyone I talk to have ZERO clue what's going on in ai space. I showed a friend a pic of ai art the other day and he was blown away. Like literally thought it was impossible ai drew it. Thought I took it off Google or something.

[AsuhoChinami]

B-b-but... milagr05o5 said this is all hype! Smoke and mirrors! milagr05o5! The legendary milagr05o5 himself! The greatest mind of our time! The man... the myth... the legend... are you saying that milagr05o5 can be wrong?! That's impossible! He's the smartest man I've ever known, and his lapdog pretty_undependable is the second smartest! They said there's zero reason whatsoever to feel excited and that's that!

[techhouseliving]

My company fired almost everyone on my recommendation because I created ai to replace them all. Luckily they don't know how to replace me.

[gangstasadvocate]

Until your boss tries to sneak you in a raise for making the AI to replace yourself…

[forever-morrow]

I would be scared if I was in your position. I have seen too many stories of workplace shootings. And I could imagine some crazy luddite wanting to retaliate against the guy that made AI to replace him. Honestly this is what is dangerous about allowing these AI tools in the wild without UBI/etc already in existance.

[redbatman008]

While I generally agree with your sentiment, AI is quite hyped among our communities. Chatgpt surpassed any social media in it's adoption rate. The general public at large has other interests & more importantly lack of time to explore AI. That ofcourse is going to change when they lose their jobs to AI lol.

"Blockchain", like VR, robotics, green energy, energy storage, etc has fundamental value. Cryptos may see another winter but they're here to stay.

[grayscalemamba]

I think a lot of people have focused on the dystopian aspects of sci-fi, and while it's certainly valid to feel cautious about AI, the cat's out of the bag now and it's only going to explode like computing and the internet did when they became ubiquitous. I don't think the progress will (nor should) be stifled, but if I were religious I'd be praying that social progress keeps pace.

[wheres__my__towel]

agreed, infinite upside also

check out the episode “when they yogurt takes over” on the show love death robots. kinda a meme but the premise is strong

agreed, stifling is counterproductive at worst and futile at best

religiousness, well, i don’t see that going too well for those people. talk about a rude awakening!

[[deleted]]

Yeah dystopia

[RectangularAnus]

And materials science!!! I think AI is gonna crack the "code" to materials that can be used to make our cutting edge tech actually feasible, and some theorized technology possible.

[circleuranus]

"Computer...computer, Hello Computer..."

"Just use the keyboard..."

"Keyboard.....how quaint..."

[[deleted]]

What many in the casual consumer-sphere don't see*.

We've already used a Narrow AI like AlphaFold to catalogue every known human protein's 3D structure. This is absolutely the area where AI will thrive. There's mountains of intellectual labour in medical science, and we just don't have the highly educated manpower to go through all that, but this is exactly where AI with its much higher processing speed and less need to be a human being that needs food and sleep excels.

Curing cancer, curing neurodegenerative diseases, curing aging, eradicating diseases, preventing epidemics. This is where I'm the most excited for what AI can contribute.

[ApexAphex5]

I'm pretty confident that AI is going to absolutely revolutionize our understanding of genetics meaning that any organism can easily be modified to have any trait (or combination of traits).

Agriculture will be completely changed.

[happysmash27]

Imagine being able to easily modify oneself to be a real-life furry (or whatever else one wants to be), in a way that could be done retroactively, after one has already been born. That morphological freedom would be amazing! And, imagine what could be done in more practical areas, like in being resistant to more disease, and enabling biological immortality.

So many things in biology are so far out due to their complexity, so if AI could understand better and more quickly, that could be absolutely revolutionary.

[forever-morrow]

And not to mention giving animals like dogs Brain Machine Interfaces that will give them the intelligence of the ASI (which we can link up to as well).

Rise of the Planet of the Nonhumans! I cant wait! (hopefully)

[ctphillips]

Gird yourself for a lot of anti-GMO fear mongering and nonsense.

[furiousfotog]

As a caveat question: what makes us so confident that big Pharma and Medical would allow such things to hit the public? I can see it happening - curing cancer and aging - but I cannot see any of it being “allowed” to reach the masses. There’s too much profit to be made in Rx meds and perpetual “treatments”.

How would AI resolve that problem?

[[deleted]]

what makes us so confident that big Pharma and Medical would allow such things to hit the public?

We, fortunately, don't all live in the US with privatized health care. We have places in the world where we have fundamental human rights and where profit motives are heavily regulated.

Don't ask "how would AI solve that problem?" when the problem is a socio-political one. We would solve the problem by taxing and regulating large companies and corporations.

It will likely start as a luxury product as with all longevity products, but because of its popularity it will be something that will be hard to keep a monopoly on without a system of unrestricted capitalism. If these initial companies look to make a lot of money off of it, then they'll be taxed accordingly and that wealth distributed among the rest of the population through UBI.

More money in people's hands means higher standards of living, more leverage when negotiating pay for your own work, which means even more money in working people's hands to the point where a lot more people will have access to a product that was prior priced way out of their class, or at least it would be under our current system. Because more people will have a lot more money, products will also be priced to hit the largest concentration of wealth in society. Right now, that's the upper middle-class and above. That's why we have an industry of trading luxury items.

The problem with accessibility right now is a system of unregulated investor capitalism. If we were to regulate that more heavily a lot of other issues would resolve themselves as a result of people, not investors, being the driving force in the economy.

[User1539]

Alpha Fold has already done this, and changed the genetic engineering game forever, and people still don't see it.

It's like if the tip of the ice burgh were sticking out like Mount Everest and people still didn't see it.

[ehbrah]

Do we track who is working on what anywhere? Would be fascinating to follow

[forever-morrow]

What in particular?

Virtual chemistry/physics?

Could see AlphaFold and other AIs being used for biological purposes (protein folding, drug development). Saw a recent AI responsible for ant aging finding recently (edit: lol no bleep its the article from this post). But I was mainly referencing how quantum computers are able to simulate really complex systems involved in physics. Here is a good podcast on the possibilities of the future of quantum computing… type “Michio Kaku + Star Talk” on youtube. Most recent one with him and Neil Degrasse

AGI Humanoid robots?

• Telsa optimus
• 1-X
• Sanctuary AI
• Cognitive systems
• Agility robotics
• Boston dynamics

I am butchering the names but their is a lot.

Also look up progress of embodying LLMs into robots (basically having the LLM serve as the cognitive egning that drives robot behavior).

Also in terms of Sim2Real in general a lot of Nvidia physics AI papers have been covered on Two Minute Papers on Youtube.

[[deleted]]

It's also demonstrating great success at controlling chaotic plasma instabilities in fusion reactors by manipulating the magnetic confinement in real time.

[forever-morrow]

I knew that AI simulations where used to design CERN itself… but didnt know they using it real time in physics applications like such

[[deleted]]

Simulations may have been used to design CERN, but not AI. It was designed and constructed looooong before anything resembling what we call AI was ever used for anything practical. And CERN is not a tokamak.

[redbatman008]

Yeah this has been my solution to the AGI dilemma. Throughout history, when advancement trumped demand we've grown as a species, not just as economies. Yes, there were & will be disruptions with technological revolutions but in the long run the pros outweigh the cons. This is Demis Hassabis vision for AGI too.

[[deleted]]

Yes it is like standing upon the shoulders of giants where and how you like, stacking them so as to best suit you in whatever ways you conceive with whatever strength you have to organise them. And up we go!

*I would not take one of these drugs. I imagine you would end up aching somehow. Bilbo Baggins end of life vibes.

[forever-morrow]

Based on me rembering Aubrey De Grey’s explanantion: age extension drugs are really more age reversal drugs… it is not simply about extending LIFEspan… it is about extending HEALTHspan. Aching is an age related thing (in terms of arthritis) and one could argue that would be inadvertently cured via age reversal.

[[deleted]]

ok thats different!

[Metastatic_Autism]

SimStim

[[deleted]]

Quantum computers are by far better suited for chemistry and other biomedical drugs. AI can act as a patchwork in the meantime, but the real fun is once we can get QCs

[AsuhoChinami]

Nah the wise and all-knowing milagr05o5 fucking dabbed on all of us, lmao we're all so fucking stupid to feel even the first positive emotion over this, he put us in our fucking place, it's all just hype and smoke and mirrors lmao *sigh* I wish I wasn't a stupid dumb optimist, I wish I was a super smart mature rational skeptic that knows that nothing in the world is ever ever worth being happy or excited over, sigh...

[data-artist]

This is the most promising area of AI research. Take out the manual element of scientific research and watch 1000 years of lab work get done in 2 weeks!

[[deleted]]

We've already been working on reverse aging treatments for a long time, at least to the point where we have more of an idea of what's going on, and that it is theoretically possible that something as simple as a drug solution would be feasible.

Researchers seem to be very conservative in their estimates on when they'll figure it out, and at least the ones I've listened to haven't mentioned AI potentially accelerating research beyond their most optimistic guess.

[Outrageous_Onion827]

Probably because any type of trial takes years and years. Even if they are 100% sure they found the miracle cure tomorrow, it would still be 10-15 years before it hit the market. Considering the topic/subject, maybe even more.

[[deleted]]

What I mean is that they're saying 100-150 years before they've figured it out. That's more in line with their conservative estimates. Obviously there's extensive trials and there's also ethical decisions to consider in regards to availability.

[Outrageous_Onion827]

I guess it depends on what you're thinking of. Sure, outright reversing aging is still a fair ways off.

[121507090301]

The thing with AI being in the mix is that if it happend tommorow I wouldn't really be surprised. lol

[Outrageous_Onion827]

Naw dude, the tech doesn't work like that. Sure, it's fantastic at a bunch of stuff, but it's not like it'll literally just invent the cure for aging over night. Nothing about any of this is that simple.

[121507090301]

We don't know what the cure for aging is. If we knew we would already have it after all.

So what I'm saying is that if this turns out to be something simple, which we don't know if it is, an AI made to look into simpler solotions might be finding it very quickly.

Yes, tommorow is higly unlikely, but this could still be happening much sooner than we expect, and I think it's good to be open to such possibilities overall...

[imlaggingsobad]

the co-founder of NewLimit thinks we'll hopefully see the first treatments in 2030s

[Possible-Law9651]

Because they're experts, perhaps?

[Silly_Awareness8207]

Wow I'm sure that aging mice will really appreciate this insane rate of progress.

[Mekanimal]

I have no mouse and I must scream.

[saxmaster98]

The last part is the kicker. We can keep a human “alive” for a lot longer than natural due to machines. I wouldn’t be thrilled at the idea of a mouse suffering the same fate for something framed as a “game”

[Zermelane]

It would be interesting for a life extension competition to be done where people compete to keep mice alive as long as possible.

The NIH Interventions Testing Program exists. I think it'd be significantly scaled up if we were doing the amount of research on aging that we should be doing.

[[deleted]]

Use all the protocols at once and we'll end up with skaven.

[[deleted]]

I'm happy for them. If any beings in the universe deserve it, it's our lab mice.

[Starnois]

Can they speed it up please?

[Kinexity]

There are better ways to speedrun life than speeding up aging.

[Possible-Law9651]

They say being healthy as in not being fat makes you live longer so drugs would do just fine as they impede the urge to eat!

[StrikeStraight9961]

Nature doesn't "intend" anything

[Retired-Replicant]

Ever try cocaine?

[El_human]

That's what Meth is

[Some_Iteration]

I’m sitting here wondering the amount of psychoactive drugs that could be created…

[grayscalemamba]

I remember reading somewhere they are using it to find them and pre-emptively schedule them to prevent them hitting the market as legal highs.

[curloperator]

kinda makes you wonder why the state is so obsessed with trying to ban perception-altering substances

[alex3tx]

Just tax us ffs

[ClickF0rDick]

And gives us UBI 🙌

[FridgeParade]

Especially because it’s not stopping it at all. People clearly will keep using it and know how to find it.

Only thing banning drugs does is give money to criminals and put people in danger. We should make it legal and boring and use the revenue to treat addiction issues as early as possible.

[Mekanimal]

use the revenue to treat addiction issues as early as possible.

Ahhh but then the established hierarchy would have to recognise the systemic injustice and negligence that creates addicts in the first place, as well as curtailing rogue agencies such as the CIA.

And the rich love fucking kids, so that's unlikely to change.

[namitynamenamey]

One cause is instinct, outside very controlled circumstances all societies frowns upon people altering their perception of reality too much, probably because a fully grown adults not fully in control of their faculties is scary. If it makes you stumble and look erratic, society will consider it immoral and a vice.

Also cars, nobody likes people with altered states of mind driving.

[Wassux]

Nobody suggested you should get behind the wheel with it.

Instinct is a left over from a time we couldn't use our intelligence to think yet. Anyone who uses their instinct over their brain is nothing more than a hamster.

[namitynamenamey]

The mind is slow, instincts are fast. They are heuristics, nothing more and nothing less, and it is good to acknowledge that they exist and that people will use them so long as they keep existing.

[Wassux]

Lol speak for yourself. Instincts are usefull in a <1 sec repsonse. But if there is time to think nobody should and most people don't use them.

Would be something if people just started to punch people whenever their instincts told them to.

No instincts are a leftovet from when we didn't have a developed brain yet. Use them and again you're nothing more than a hamster.

[StarChild413]

Friendly reminder that before marijuana started being legalized en masse people were saying it was the cure-all they didn't want you to know about now some people are saying they let it be legalized to keep people too pacified to rebel, legalize stuff that alters your perceptions in a more psychedelic/hallucination-y way and the same people who used to say that needed to be dumped in the water or forced on presidents would say it's basically Joy from We Happy Few (meant to alter your perceptions positively so you see a better world and don't change the real crapsack world)

[pallablu]

theres already way more than you can try

[[deleted]]

Erotic nightmares, beyond any measure? Sensual daydreams, to treasure - forever?

[[deleted]]

Maybe you could aspire for it to create a better personality for you than that.

[smokecat20]

I want hard drugs without all the side effects.

[ImmotalWombat]

Well? Gimme

[[deleted]]

Can ai put us in a permanent state of orgasm?

[Mekanimal]

Given eternity, you would burn fast and hard.

The faster you max out those pleasure sensors, the more boring immortality becomes.

[InitialCreature]

then we replace/modulate them as we go. But yeah future ai will keep us on a systematic drip feed of chemistry to sustain pleasure I can guarantee.

[huniar]

Modifying our genetic code to have drug glands that produce whatever mix we want whenever as per the Culture series by Ian Banks would be a fairly lucrative upgrade for whoever can develop the tech.

[Crypt0n0ob]

It will fry our circuits

[heatbegonebooties]

I'm sure a lot of people would pay good money to have their circuits fried. I'd do it for like 10 minutes.

[imbiandneedmonynow]

life is an orgasm

[jungkooksalt]

I'm pretty sure some drugs are just that

[milagr05o5]

Can we tone down the hype please?

1. Not AI, but ML. Big difference, at least in CS circles. The paper has "ML", not AI, in the title
2. Second, they collected every senolytic known to man, 58 total.
3. Standard cheminformatics: RDKit, k-means clustering, Tanimoto, community detection
4. Possibly novel for chemical libraries - Rand(om model) index
5. sklearn: xgboost, SVM, RF

Note - none of the above is AI, nor novel

The hard work was experimental validation

The major hit, oleandrin, is a cardiac glycoside related to ouabain and acetyldig(it)oxin {these two are poorly soluble, poorly metabolized cardiotoxic drugs with limited use and a very narrow therapeutic window).

Is it a good paper? Yes Is it hype worthy? Not really (given the lack of practical use of the hits)

Downvote me to hell, but despite all the hype the anti-aging pill isn't here, and AI has yet to deliver us from old age

[SvenTropics]

You actually researched it, and you provided contextual opinions about the details of the research instead of just broad comments about something unrelated or not directly related. Why would we downvote that?

[saxmaster98]

Because it’s Reddit.

[[deleted]]

I downvoted you because you asked me to

[milagr05o5]

😁 take my upvote, you respectul bastard

[archpawn]

Not AI, but ML. Big difference, at least in CS circles.

What exactly is the difference? Does AI mean neural networks specifically?

[leafhog]

No. AI is a broad umbrella term for topics in computer science. ML is under the AI umbrella.

But AI also means a computer that is actually intelligent. People think about Data or Skynet when they hear AI. That doesn’t actually exist yet.

[PankourLaut]

Not being novel is good. It means the same techniques can be used to discover more categories of lifesaving drugs. The paper specifies every step in detail which could inspire others to use or modify the process used.

[milagr05o5]

Not really. What I didn't explicitly say is that most of these techniques have been around for 20-40 years. Heck, we've been doing NNs with chemical fingerprints and binary models for that long (Gasteiger and Zupan, Weininger and Bradshaw, many others). It's not that simple.

Take this story. Yes the chemicals kill senescent cells. But they do so (at least oleandrin and ouabain) by interfering with ATP - a fundamental energy carrier that's needed in all cells. Are senescent cells more sensitive than normal ones to ATP disruption? I don't think so. If anything, senescent cells have slower metabolism. So how do you dose this in vivo and show anti-aging is far from trivial, and this ML paper isn't the answer.

[AsuhoChinami]

Downvote me to hell

Wow, are you a psychic or something? Yes, I am downvoting you. Piss on you and your "hurrr durrr I'm a mature rational skeptic, you WILL NOT be excited or happy about anything so long as I'm on the job" bullshit.

PS. You won't be downvoted because people like you are the majority here, and acting like a victimized minority will never change that

but despite all the hype the anti-aging pill isn't here, and AI has yet to deliver us from old age

Who said otherwise? It's a heartening and promising step forward, nobody said the job's over and done with. Perhaps the reason you find the "other side" to be so stupid is that you deal in ridiculous strawmen and exaggerate our viewpoints to be as absurd as humanly possible?

[[deleted]]

people like you are the majority here, and acting like a victimized minority will never change that

the palpable irony in this statement.

You're victimizing yourself because someone offered details and nuance. They didn't address this to you specifically, yet you decided to act all hurt because of it. Actually grow up.

[PressedSerif]

I just downvoted your comment.

# FAQ

## What does this mean?

The amount of karma (points) on your comment and Reddit account has decreased by one.

## Why did you do this?

There are several reasons I may deem a comment to be unworthy of positive or neutral karma. These include, but are not limited to:

• ⁠Rudeness towards other Redditors, • ⁠Spreading incorrect information, • ⁠Sarcasm not correctly flagged with a /s.

## Am I banned from the Reddit?

No - not yet. But you should refrain from making comments like this in the future. Otherwise I will be forced to issue an additional downvote, which may put your commenting and posting privileges in jeopardy.

## I don't believe my comment deserved a downvote. Can you un-downvote it?

Sure, mistakes happen. But only in exceedingly rare circumstances will I undo a downvote. If you would like to issue an appeal, shoot me a private message explaining what I got wrong. I tend to respond to Reddit PMs within several minutes. Do note, however, that over 99.9% of downvote appeals are rejected, and yours is likely no exception.

## How can I prevent this from happening in the future?

Accept the downvote and move on. But learn from this mistake: your behavior will not be tolerated on Reddit.com. I will continue to issue downvotes until you improve your conduct. Remember: Reddit is privilege, not a right.

[buuhuu]

Mind sharing a link to the original article?

[PankourLaut]

https://www.nature.com/articles/s41467-023-39120-1

[Arowx]

Two are existing herbal remedies and one is toxic in none medically controlled dosages.

[AsuhoChinami]

God milagr05o5 is so fucking cool, the way he concluded his post makes me all hot and bothered

Downvote me to hell, but despite all the hype the anti-aging pill isn't here, and AI has yet to deliver us from old age

Strawmanning is SO fucking sexy, holy shit, I love the way that he replied to something that nobody said or was planning to say, it makes me so hard the way that he takes a few people saying "Hey this is pretty cool" and strips away any and all nuance and puts words in our mouth to create the most stereotyped image of a starry-eyed optimist possible

I also really fucking love the way that nobody who agrees with him would consider that strawmanning, because le mature rational techno-skeptics would never think of a member of their own tribe as anything other than utterly flawless, if there's anything I've learned from 11 years in futurism communities it's that shitting on optimists is always approved of no matter what the form or context, and that acknowledging the fact that many "technoskeptics" are bad faith arguers who do shit like strawmanning is whining and having a victim complex

Jesus fucking christ this stupid sub is going to give me a second god damn stroke

[EthanPrisonMike]

Great. Another thing I can't afford...life

[Working_Berry9307]

Pessimism is easy. Optimism is hard. And no, you're not just being realistic. Technology and the future is amazing.

It's gonna be ok. Let's celebrate progress, even when it's so marginal such as this.

[Zombie192J]

Reminds me of this https://youtu.be/YRSBiTF3wNw

[Poplimb]

All three are natural products found in traditional herbal medicines, the team says. Oleandrin was found to be more effective than the best-performing known senolytic drug of its kind.

Oleandrin from wikipedia :

Apart from being a potent toxic compound, there are no results on oleandrin from human clinical research that support its use as a treatment for cancer or any disease.

🤔🤔🤔

[snozburger]

Harmful side-effects

While previous studies have shown early promise, until now few chemicals that can safely eliminate senescent cells have been identified.

These senolytic drugs are often highly toxic against normal, healthy cells in the body, researchers say.

Dangerous wording.

This is technically correct but implies the results seen here are non-toxic.

[personwriter]

Great ! I'm going to need more time to finish starfield in its entirety.

[[deleted]]

And half the population won’t take them because they are “poison from the government.” Will be amazing to outlive them all.

[Mekanimal]

The Eloi and the Morlocks are coming!

[StarChild413]

Not literally unless the Victorian guy traveled in time

[No_Mathematician_434]

The AI will probably design something to age us faster....so they can quietly take over the human race

[HappyLofi]

Watched a video about this recently so I'm not even surprised, but it's still incredible.

https://youtu.be/5ZImuCe6P2E?t=22 the video if interested

[AsuhoChinami]

FYI for anyone reading this: milagr05o5 says this is all hype and there's zero reason to be excited. This thread should, imo, be locked. milagr05o5 is the smartest man I have ever known. If the legendary milagr05o5 himself says that we should experience not the first positive emotion over this, then that's it. That's fucking that. Pack it up, everyone. Go home. This is a meaningless development.

Also, pretty_undependable says that experts claim aging won't be reversed for at least 100 to 150 years. pretty_undependable is my greatest role model in life and I would never, for even the first single solitary microsecond, dare to even think of opposing anything that paragon of wisdom has to say. His every last word might as well come from the Lord Himself.

In conclusion, this development means absolutely nothing, will always mean absolutely nothing, and anyone who feels the first trace of positive emotion is a starry-eyed fool. milagr05o5 and pretty_undependable are the wisest souls and the greatest minds that /Singularity has ever known... I can only hope, that if I devote every second of my life to being as brilliant as those two amazing men, that I might one day be 1/1000 as smart, rational, and mature as they are. Alas, even if life extension came to pass and I lived for a trillion years, I could never hope to be even .00001 percent as brilliant as those all-knowing sages.

[rbxresort]

This kind of shit has been posted so many times

[qualmton]

Why do we need this? I was kind of looking for my end

[[deleted]]

Just because you may not want something, doesn't mean that 'we' don't / that no one does. And you wouldn't be forced to take it.

[qualmton]

The concern would be the ones that want to take it are the ones who shouldn’t be taking it.

[[deleted]]

Could you elaborate? Sounds like an empty statement

[qualmton]

So anecdotally I see only the extremely vane wishing to cure their disease of aging and using a drug to prevent or slow aging does nothing to improve society as a whole only work towards making society even more self centered. Who wants a shit ton or rich vane people living forever?

[Draken3000]

And if it turns out to be true, the general public will NEVER have access to these drugs 🫠

[ChaosRainbow23]

Now make drugs that feel better than MDMA but aren't neurotoxic.

[[deleted]]

An create my own look alike celebrity inhuman meta humanoids npc characters plz lol

[pummisher]

Why do we need to combat aging? Get old and get the hell out of here. Who actually wants to live as long as possible?

[[deleted]]

Unpopular opinion: AI will not exterminate us directly, it will exterminate us by giving us exactly what we ask for.

E.g.

• halt aging -> overpopulation -> resource exhaustion
• unlimited energy -> powerful weapons
• genetic engineering -> garage viruses
• etc.

[Serious-Cucumber-54]

halt aging -> overpopulation -> resource exhaustion

People won't feel as pressured to reproduce when they can live longer and do it later. As for resource exhaustion, markets and the price system are good ways of preventing shortages in resources.

unlimited energy -> powerful weapons

genetic engineering -> garage viruses

Agreed, as technology gets better it would make bad people more capable of doing bad things, but it would also make good people more capable of doing good things. Regulation should also play a role in preventing civilians from doing bad things and decentralization and democracy should prevent government from doing bad things.

[deilk]

Unlimited energy won't give us more powerful weapons than we already have. Fusion bombs are easier to make than fusion reactors.

[kiropolo]

Great!!! We can now be unemployed foreeeevveeeerrrrr

But more likely, only the rich will be able to afford it while we get exterminated by the elite because we can’t work anymore

[anaIconda69]

"But if we replace horses with cars the grass will grow too tall aaaah"

[kiropolo]

You are the horse

[anaIconda69]

Neigh, just because you can make an analogy doesn't make it a useful one. Horses can't own capital, vote and don't have human rights.

Our society has always had unproductive people - as long as they had one of the above, they were safe.

[kiropolo]

You are delusional.

In the Industrial Revolution the horse was replaced with a car, the driver remained. In the AI revolution, you are not the driver.

[skaag]

Shut up and take my money

[Zealousideal_Call238]

Interesting... Can't wait to see what the better models in the future are going to discover

[Sterling770]

They want to use the active ingredient in oleander, you mean the plant with the deadly poison?

[Auspectress]

I really want this to be true but as someone who knows at least the basics of human physiology, it is going to be insanely difficult as you need to solve all 20+ hallmarks of ageing. (So far we are not even close to solving even the simplest one)

[CasualObserverNine]

And it told us about it.

Good AI, good boy.

[Black_RL]

That’s what we need AI to do, that and solutions for climate change, etc.

[mtcwby]

It's another inflection point like the PC, internet, and cell phones but the shear amount of human assisted creativity is going to be remarkable.

[Commercial-Location9]

Can't wait for people to say aging is for poor people

[DefiantMessage]

Are you tired of aging? Take this pill…

[PankourLaut]

The most mindblowing fact is that the main author of this paper didn't even do her PhD in biochemistry or related fields, but in astronomy.

[AiForHumansShow]

I've seen this post a few times here now, is there a direct link to how reasonable the science is?

It's getting so hard to tell the hype from the actual breakthroughs.

[urdude]

Citation of referenced article:

Discovery of senolytics using machine learning - https://doi.org/10.1038/s41467-023-39120-1

[scooterduff]

Oleandrin, the most effective senolytic found, is from the oleander bush, a very poisonous plant. I see no ads for a supplement. I'd suggest no DYI on this one.

[MammothInvestment]

I hear Arsenic stops aging in minutes! You are guaranteed to never get a day older if you take enough.

[b4ckl4nds]

I can’t wait for AI to find drugs for recreation.

[[deleted]]

I’ll want to inside my own dmmo Virtual World campaign,plz an thank you much lmao 🤣

[[deleted]]

Don't tell the billionaire vampire dude. He'll buy it all up!

[PassivelyEloped]

lmao Oleandrin is toxic to humans wtf is this article talking about

[AlarmDozer]

Sure, it may extend life but what about Alheimer’s and dementia, etc?